Abstract
T-cell clones derived from the CSF (cerebrospinal fluid) of MS (multiple sclerosis) patients have been analysed for the production of interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2) and interleukin-4 (IL-4). Each CSF-T clone (both CD4+ and CD8+) produced substantial amounts of IFN-gamma and especially TNF-alpha compared with autologous peripheral T clones and liver-infiltrating T clones from patients with chronic active hepatitis. The large quantities of TNF produced by CSF-T cell clones suggest an important role for this cytokine in MS immunopathogenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 79-83 |
| Number of pages | 5 |
| Journal | Italian Journal of Neurological Sciences |
| Volume | 13 |
| Issue number | 9 Suppl 14 |
| Publication status | Published - Dec 1992 |
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
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Cite this
Buttinelli, C., Toma, L., Falcone, M. M., Salvetti, M., Ristori, G., Barnaba, V., & Fieschi, C. (1992). Tumour necrosis factor-alpha synthesis by cerebrospinal-fluid-derived T cell clones from patients with multiple sclerosis. Italian Journal of Neurological Sciences, 13(9 Suppl 14), 79-83.