Tumour necrosis factor-alpha synthesis by cerebrospinal-fluid-derived T cell clones from patients with multiple sclerosis.

C. Buttinelli; L. Toma; M. M. Falcone; M. Salvetti; G. Ristori; V. Barnaba; C. Fieschi

Tumour necrosis factor-alpha synthesis by cerebrospinal-fluid-derived T cell clones from patients with multiple sclerosis.

C. Buttinelli, L. Toma, M. M. Falcone, M. Salvetti, G. Ristori, V. Barnaba, C. Fieschi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

T-cell clones derived from the CSF (cerebrospinal fluid) of MS (multiple sclerosis) patients have been analysed for the production of interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2) and interleukin-4 (IL-4). Each CSF-T clone (both CD4+ and CD8+) produced substantial amounts of IFN-gamma and especially TNF-alpha compared with autologous peripheral T clones and liver-infiltrating T clones from patients with chronic active hepatitis. The large quantities of TNF produced by CSF-T cell clones suggest an important role for this cytokine in MS immunopathogenesis.

Original language	English
Pages (from-to)	79-83
Number of pages	5
Journal	Italian Journal of Neurological Sciences
Volume	13
Issue number	9 Suppl 14
Publication status	Published - Dec 1992

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

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Tumour necrosis factor-alpha synthesis by cerebrospinal-fluid-derived T cell clones from patients with multiple sclerosis. / Buttinelli, C.; Toma, L.; Falcone, M. M.; Salvetti, M.; Ristori, G.; Barnaba, V.; Fieschi, C.

In: Italian Journal of Neurological Sciences, Vol. 13, No. 9 Suppl 14, 12.1992, p. 79-83.

Research output: Contribution to journal › Article › peer-review

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abstract = "T-cell clones derived from the CSF (cerebrospinal fluid) of MS (multiple sclerosis) patients have been analysed for the production of interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2) and interleukin-4 (IL-4). Each CSF-T clone (both CD4+ and CD8+) produced substantial amounts of IFN-gamma and especially TNF-alpha compared with autologous peripheral T clones and liver-infiltrating T clones from patients with chronic active hepatitis. The large quantities of TNF produced by CSF-T cell clones suggest an important role for this cytokine in MS immunopathogenesis.",

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AU - Buttinelli, C.

AU - Toma, L.

AU - Falcone, M. M.

AU - Salvetti, M.

AU - Ristori, G.

AU - Barnaba, V.

AU - Fieschi, C.

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N2 - T-cell clones derived from the CSF (cerebrospinal fluid) of MS (multiple sclerosis) patients have been analysed for the production of interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2) and interleukin-4 (IL-4). Each CSF-T clone (both CD4+ and CD8+) produced substantial amounts of IFN-gamma and especially TNF-alpha compared with autologous peripheral T clones and liver-infiltrating T clones from patients with chronic active hepatitis. The large quantities of TNF produced by CSF-T cell clones suggest an important role for this cytokine in MS immunopathogenesis.

AB - T-cell clones derived from the CSF (cerebrospinal fluid) of MS (multiple sclerosis) patients have been analysed for the production of interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2) and interleukin-4 (IL-4). Each CSF-T clone (both CD4+ and CD8+) produced substantial amounts of IFN-gamma and especially TNF-alpha compared with autologous peripheral T clones and liver-infiltrating T clones from patients with chronic active hepatitis. The large quantities of TNF produced by CSF-T cell clones suggest an important role for this cytokine in MS immunopathogenesis.

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Tumour necrosis factor-alpha synthesis by cerebrospinal-fluid-derived T cell clones from patients with multiple sclerosis.

Abstract

ASJC Scopus subject areas

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