Abstract
T-cell clones derived from the CSF (cerebrospinal fluid) of MS (multiple sclerosis) patients have been analysed for the production of interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2) and interleukin-4 (IL-4). Each CSF-T clone (both CD4+ and CD8+) produced substantial amounts of IFN-gamma and especially TNF-alpha compared with autologous peripheral T clones and liver-infiltrating T clones from patients with chronic active hepatitis. The large quantities of TNF produced by CSF-T cell clones suggest an important role for this cytokine in MS immunopathogenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 79-83 |
| Number of pages | 5 |
| Journal | Italian Journal of Neurological Sciences |
| Volume | 13 |
| Issue number | 9 Suppl 14 |
| Publication status | Published - Dec 1992 |
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ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Tumour necrosis factor-alpha synthesis by cerebrospinal-fluid-derived T cell clones from patients with multiple sclerosis. / Buttinelli, C.; Toma, L.; Falcone, M. M.; Salvetti, M.; Ristori, G.; Barnaba, V.; Fieschi, C.
In: Italian Journal of Neurological Sciences, Vol. 13, No. 9 Suppl 14, 12.1992, p. 79-83.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tumour necrosis factor-alpha synthesis by cerebrospinal-fluid-derived T cell clones from patients with multiple sclerosis.
AU - Buttinelli, C.
AU - Toma, L.
AU - Falcone, M. M.
AU - Salvetti, M.
AU - Ristori, G.
AU - Barnaba, V.
AU - Fieschi, C.
PY - 1992/12
Y1 - 1992/12
N2 - T-cell clones derived from the CSF (cerebrospinal fluid) of MS (multiple sclerosis) patients have been analysed for the production of interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2) and interleukin-4 (IL-4). Each CSF-T clone (both CD4+ and CD8+) produced substantial amounts of IFN-gamma and especially TNF-alpha compared with autologous peripheral T clones and liver-infiltrating T clones from patients with chronic active hepatitis. The large quantities of TNF produced by CSF-T cell clones suggest an important role for this cytokine in MS immunopathogenesis.
AB - T-cell clones derived from the CSF (cerebrospinal fluid) of MS (multiple sclerosis) patients have been analysed for the production of interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2) and interleukin-4 (IL-4). Each CSF-T clone (both CD4+ and CD8+) produced substantial amounts of IFN-gamma and especially TNF-alpha compared with autologous peripheral T clones and liver-infiltrating T clones from patients with chronic active hepatitis. The large quantities of TNF produced by CSF-T cell clones suggest an important role for this cytokine in MS immunopathogenesis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027010654&partnerID=8YFLogxK
M3 - Article
C2 - 1345744
AN - SCOPUS:0027010654
VL - 13
SP - 79
EP - 83
JO - Italian Journal of Neurological Sciences
JF - Italian Journal of Neurological Sciences
SN - 0392-0461
IS - 9 Suppl 14
ER -