Tumour necrosis factor family genes in a phenotype of COPD associated with emphysema

I. Ferrarotti, M. Zorzetto, M. Beccaria, L. S. Gilè, R. Porta, N. Ambrosino, P. F. Pignatti, I. Cerveri, E. Pozzi, M. Luisetti

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Genetic factors are believed to play a role in the individual susceptibility to chronic obstructive pulmonary disease (COPD). Tumour necrosis factor (TNF) family genes have been widely investigated but inconsistent results may lie either in the genetic heterogeneity of populations or in the poor phenotype definition. A genetic study was performed using a narrower phenotype of COPD. The authors studied 86 healthy smokers and 63 COPD subjects who were enrolled based on irreversible airflow obstruction (forced expiratory volume in one second/forced vital capacity

Original languageEnglish
Pages (from-to)444-449
Number of pages6
JournalEuropean Respiratory Journal
Volume21
Issue number3
Publication statusPublished - Mar 1 2003

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Emphysema
Chronic Obstructive Pulmonary Disease
Tumor Necrosis Factor-alpha
Phenotype
Genes
Genetic Heterogeneity
Vital Capacity
Forced Expiratory Volume
Population

Keywords

  • Association study
  • Candidate gene
  • Complex traits
  • Gene polymorphisms
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Tumour necrosis factor family genes in a phenotype of COPD associated with emphysema. / Ferrarotti, I.; Zorzetto, M.; Beccaria, M.; Gilè, L. S.; Porta, R.; Ambrosino, N.; Pignatti, P. F.; Cerveri, I.; Pozzi, E.; Luisetti, M.

In: European Respiratory Journal, Vol. 21, No. 3, 01.03.2003, p. 444-449.

Research output: Contribution to journalArticle

Ferrarotti, I, Zorzetto, M, Beccaria, M, Gilè, LS, Porta, R, Ambrosino, N, Pignatti, PF, Cerveri, I, Pozzi, E & Luisetti, M 2003, 'Tumour necrosis factor family genes in a phenotype of COPD associated with emphysema', European Respiratory Journal, vol. 21, no. 3, pp. 444-449.
Ferrarotti, I. ; Zorzetto, M. ; Beccaria, M. ; Gilè, L. S. ; Porta, R. ; Ambrosino, N. ; Pignatti, P. F. ; Cerveri, I. ; Pozzi, E. ; Luisetti, M. / Tumour necrosis factor family genes in a phenotype of COPD associated with emphysema. In: European Respiratory Journal. 2003 ; Vol. 21, No. 3. pp. 444-449.
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