TY - JOUR
T1 - Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer
T2 - a multicentre study within the INHANCE consortium
AU - Leoncini, Emanuele
AU - Vukovic, Vladimir
AU - Cadoni, Gabriella
AU - Giraldi, Luca
AU - Pastorino, Roberta
AU - Arzani, Dario
AU - Petrelli, Livia
AU - Wünsch-Filho, Victor
AU - Toporcov, Tatiana Natasha
AU - Moyses, Raquel Ayub
AU - Matsuo, Keitaro
AU - Bosetti, Cristina
AU - la Vecchia, Carlo
AU - Serraino, Diego
AU - Simonato, Lorenzo
AU - Merletti, Franco
AU - Boffetta, Paolo
AU - Hashibe, Mia
AU - Lee, Yuan Chin Amy
AU - Boccia, Stefania
PY - 2018/5/19
Y1 - 2018/5/19
N2 - Recurrence and second primary cancer (SPC) continue to represent major obstacles to long-term survival in head and neck cancer (HNC). Our aim was to evaluate whether established demographics, lifestyle-related risk factors for HNC and clinical data are associated with recurrence and SPC in HNC. We conducted a multicentre study by using data from five studies members of the International Head and Neck Cancer Epidemiology consortium—Milan, Rome, Western Europe, Sao Paulo, and Japan, totalling 4005 HNC cases with a median age of 59 (interquartile range 52–67). Multivariate hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for recurrence and SPC. During follow-up, 1161 (29%) patients had recurrence and 343 (8.6%) developed SPC. Advanced tumour stage was associated with increased risk of recurrence in HNC overall (HR = 1.76, 95% CI 1.41–2.19). Women with laryngeal cancer had a reduced risk of recurrence compared to men (HR = 0.39, 95% CI: 0.24–0.74). Concerning predictors of SPC, advanced age (HR = 1.02; 95% CI: 1.00–1.04) and alcohol consumption (> 1 drink per day, HR = 2.11; 95% CI: 1.13–3.94) increased the risk of SPC among patients with laryngeal cancer. Additionally, women were at higher risk of SPC, in HNC overall group (HR = 1.68; 95% CI: 1.13–2.51) and oropharyngeal cancer group (HR = 1.74; 95% CI: 1.02–2.98). Tumour stage and male gender (larynx only) were positive predictors of cancer recurrence in HNC patients. Predictors of SPC were advanced age and alcohol use among laryngeal cancer cases, and female gender for oropharyngeal and HNC overall.
AB - Recurrence and second primary cancer (SPC) continue to represent major obstacles to long-term survival in head and neck cancer (HNC). Our aim was to evaluate whether established demographics, lifestyle-related risk factors for HNC and clinical data are associated with recurrence and SPC in HNC. We conducted a multicentre study by using data from five studies members of the International Head and Neck Cancer Epidemiology consortium—Milan, Rome, Western Europe, Sao Paulo, and Japan, totalling 4005 HNC cases with a median age of 59 (interquartile range 52–67). Multivariate hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for recurrence and SPC. During follow-up, 1161 (29%) patients had recurrence and 343 (8.6%) developed SPC. Advanced tumour stage was associated with increased risk of recurrence in HNC overall (HR = 1.76, 95% CI 1.41–2.19). Women with laryngeal cancer had a reduced risk of recurrence compared to men (HR = 0.39, 95% CI: 0.24–0.74). Concerning predictors of SPC, advanced age (HR = 1.02; 95% CI: 1.00–1.04) and alcohol consumption (> 1 drink per day, HR = 2.11; 95% CI: 1.13–3.94) increased the risk of SPC among patients with laryngeal cancer. Additionally, women were at higher risk of SPC, in HNC overall group (HR = 1.68; 95% CI: 1.13–2.51) and oropharyngeal cancer group (HR = 1.74; 95% CI: 1.02–2.98). Tumour stage and male gender (larynx only) were positive predictors of cancer recurrence in HNC patients. Predictors of SPC were advanced age and alcohol use among laryngeal cancer cases, and female gender for oropharyngeal and HNC overall.
KW - Head and neck cancer
KW - Predictors
KW - Preventive
KW - Recurrence
KW - Second primary cancer
UR - http://www.scopus.com/inward/record.url?scp=85047137111&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047137111&partnerID=8YFLogxK
U2 - 10.1007/s10654-018-0409-5
DO - 10.1007/s10654-018-0409-5
M3 - Article
C2 - 29779202
AN - SCOPUS:85047137111
SP - 1
EP - 14
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
SN - 0393-2990
ER -