Tumour sublines with different metastatic capacity induce similar blood coagulation changes in the host

F. Delaini, R. Giavazzi, G. de Bellis Vitti, G. Alessandri, A. Mantovani, M. B. Donati

Research output: Contribution to journalArticle

Abstract

This paper is aimed at investigating how metastatic tumour growth influenced the haemostatic system of the host. Blood platelet count, blood fibrinogen level, the activated partial thromboplastin time (APTT) and the prothrombin time (PT) were determined at various intervals during growth and metastasis of a murine fibrosarcoma (mFS6) or one of its sublines with different metastatic capacity. Progressive thrombocytopenia and increase in fibrinogen level were observed during development of the tumour in all the animal groups studied, irrespective of the metastatic potential of the various sublines. No significant changes were observed in the PT or APTT values. These data support the concept that primary rather than metastatic growth influences the haemostatic system of tumour-bearing animals.

Original languageEnglish
Pages (from-to)100-104
Number of pages5
JournalBritish Journal of Cancer
Volume43
Issue number1
DOIs
Publication statusPublished - 1981

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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