Tumour volume and high grade tumour volume are the best predictors of pathologic stage and biochemical recurrence after radical prostatectomy

Felix K H Chun, Alberto Briganti, Claudio Jeldres, Andrea Gallina, Andreas Erbersdobler, Thorsten Schlomm, Jochen Walz, Christian Eichelberg, Georg Salomon, Alexander Haese, Eike Currlin, Sascha A. Ahyai, François Bénard, Hartwig Huland, Markus Graefen, Pierre I. Karakiewicz

Research output: Contribution to journalArticlepeer-review


Introduction: Our goal was to examine to what extent tumour volume (TV) and percentage of high grade tumour volume (%HGTV) affect the rate of positive surgical margins and the rate of biochemical recurrence after radical prostatectomy. Materials and methods: TV and %HGTV were routinely planimetrically quantified in a cohort of 780 consecutive patients. Mean follow-up was 46.7 months. Multivariable regression models addressed two separate endpoints: positive surgical margins and biochemical recurrence. The increase in model predictive accuracy related to the addition of TV and %HGTV to radical prostatectomy stage and grade was assessed, after 200 bootstrap resamples to reduce overfit bias. Results: In multivariable logistic regression models addressing positive surgical margins rate, predictive accuracy increased by 1.9% (p <0.001) when TV was added to other covariates. No further increment was noted when %HGTV was added (p = 0.3). In multivariable Cox regression models addressing biochemical recurrence, accuracy increased by 0.6% (p = 0.002) when TV was added and an additional increase of 0.7% was recorded when %HGTV (p <0.001) was added. Conclusion: Tumour bulk reflected by TV affects local cancer control rate, which is reflected in the rate of positive surgical margins. Conversely, high grade cancer determines the rate of biochemical recurrence. These two variables represent the most powerful predictors of cancer control in men treated for localised prostate cancer. Moreover, they increase the ability of established predictors to predict the outcomes of interest. In consequence, they warrant consideration in future predictive and prognostic tools.

Original languageEnglish
Pages (from-to)536-543
Number of pages8
JournalEuropean Journal of Cancer
Issue number3
Publication statusPublished - Feb 2007


  • Biochemical recurrence
  • Prostate cancer
  • Radical prostatectomy
  • Tumour volume

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology


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