Tuning of a deformable image registration procedure for skin component mechanical properties assessment

E. Montin, E. Cutrì, G. Spadola, A. Testori, G. Pennati, L. Mainardi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Several studies report the mechanical properties of skin tissues but their values largely depend on the measurement method. Therefore, we investigated the feasibility of recognizing the cellular constituents mechanical properties of pigmented skin by Confocal Laser Scanner Microscopy (CLSM). With this purpose, an healthy volunteer was examined in three areas nearby a pigmented skin lesion in two configurations: deforming and non deforming the nevus. The tissue displacement of the nevus was then assessed by means of deformable registration of the images in these two configurations. There are several registration strategy able to overcome this task, among them, we proposed two methods with different deformation models: a Free Form Deformation (FFD) model based on b-spline and a second one based on Demons Registration Algorithm (DRA). These two strategies need the definition of several parameters in order to obtain optimal registration performances. Thus, we tuned these parameters by means of simulated data and evaluated their registration abilities on the real in vivo CLSM acquisitions in the two configurations. The results showed that the registration using DRA had a better performance in comparison to the FFD one, in particular in two out of the three areas the DRA performance was significantly better than the FFD one. The registration procedure highlighted deformation differences among the chosen areas.

Original languageEnglish
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages6305-6308
Number of pages4
Volume2015-November
ISBN (Print)9781424492718
DOIs
Publication statusPublished - Nov 4 2015
Event37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy
Duration: Aug 25 2015Aug 29 2015

Other

Other37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
CountryItaly
CityMilan
Period8/25/158/29/15

Fingerprint

Image registration
Confocal Microscopy
Skin
Tuning
Mechanical properties
Nevus
Microscopic examination
Tissue
Lasers
Healthy Volunteers
Splines

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Montin, E., Cutrì, E., Spadola, G., Testori, A., Pennati, G., & Mainardi, L. (2015). Tuning of a deformable image registration procedure for skin component mechanical properties assessment. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (Vol. 2015-November, pp. 6305-6308). [7319834] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2015.7319834

Tuning of a deformable image registration procedure for skin component mechanical properties assessment. / Montin, E.; Cutrì, E.; Spadola, G.; Testori, A.; Pennati, G.; Mainardi, L.

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November Institute of Electrical and Electronics Engineers Inc., 2015. p. 6305-6308 7319834.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Montin, E, Cutrì, E, Spadola, G, Testori, A, Pennati, G & Mainardi, L 2015, Tuning of a deformable image registration procedure for skin component mechanical properties assessment. in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. vol. 2015-November, 7319834, Institute of Electrical and Electronics Engineers Inc., pp. 6305-6308, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015, Milan, Italy, 8/25/15. https://doi.org/10.1109/EMBC.2015.7319834
Montin E, Cutrì E, Spadola G, Testori A, Pennati G, Mainardi L. Tuning of a deformable image registration procedure for skin component mechanical properties assessment. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November. Institute of Electrical and Electronics Engineers Inc. 2015. p. 6305-6308. 7319834 https://doi.org/10.1109/EMBC.2015.7319834
Montin, E. ; Cutrì, E. ; Spadola, G. ; Testori, A. ; Pennati, G. ; Mainardi, L. / Tuning of a deformable image registration procedure for skin component mechanical properties assessment. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November Institute of Electrical and Electronics Engineers Inc., 2015. pp. 6305-6308
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