Tuning of innate immunity and polarized responses by decoy receptors

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

After the identification of the interleukin (IL)-1 type II receptor as the prototype, decoy receptors have been identified for a number of members of the IL-1/IL-18, TNF, IL-10 and IL-13 receptor families. Moreover, the silent receptor D6 is a promiscuous decoy and scavenger receptor of inflammatory chemokines. The IL-1 decoy receptor is regulated by pro- and anti-inflammatory signals and its levels may serve as a readout of the activation of anti-inflammatory pathways, for instance by glucocorticoid hormones. Decoy receptors represent a strategy to tune inflammatory and polarized adaptive responses.

Original languageEnglish
Pages (from-to)109-115
Number of pages7
JournalInternational Archives of Allergy and Immunology
Volume132
Issue number2
DOIs
Publication statusPublished - 2003

Fingerprint

Innate Immunity
Interleukin-1 Type II Receptors
Interleukin-13 Receptors
Anti-Inflammatory Agents
Scavenger Receptors
Interleukin-18
Interleukin-1 Receptors
Interleukin-1
Chemokines
Interleukin-10
Glucocorticoids
Hormones

Keywords

  • Adaptive immunity
  • Chemokines
  • Decoy receptors
  • Inflammation
  • Interleukin-1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

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T1 - Tuning of innate immunity and polarized responses by decoy receptors

AU - Mantovani, Alberto

AU - Bonecchi, Raffaella

AU - Martinez, Fernando O.

AU - Galliera, Emanuela

AU - Perrier, Patrick

AU - Allavena, Paola

AU - Locati, Massimo

PY - 2003

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AB - After the identification of the interleukin (IL)-1 type II receptor as the prototype, decoy receptors have been identified for a number of members of the IL-1/IL-18, TNF, IL-10 and IL-13 receptor families. Moreover, the silent receptor D6 is a promiscuous decoy and scavenger receptor of inflammatory chemokines. The IL-1 decoy receptor is regulated by pro- and anti-inflammatory signals and its levels may serve as a readout of the activation of anti-inflammatory pathways, for instance by glucocorticoid hormones. Decoy receptors represent a strategy to tune inflammatory and polarized adaptive responses.

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KW - Chemokines

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KW - Inflammation

KW - Interleukin-1

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