Tuning of nanoparticle biological functionality through controlled surface chemistry and characterisation at the bioconjugated nanoparticle surface

Delyan R. Hristov, Louise Rocks, Philip M. Kelly, Steffi S. Thomas, Andrzej S. Pitek, Paolo Verderio, Eugene Mahon, Kenneth A. Dawson

Research output: Contribution to journalArticle

Abstract

We have used a silica-PEG based bionanoconjugate synthetic scheme to study the subtle connection between cell receptor specific recognition and architecture of surface functionalization chemistry. Extensive physicochemical characterization of the grafted architecture is capable of capturing significant levels of detail of both the linker and grafted organization, allowing for improved reproducibility and ultimately insight into biological functionality. Our data suggest that scaffold details, propagating PEG layer architecture effects, determine not only the rate of uptake of conjugated nanoparticles into cells but also, more significantly, the specificity of pathways via which uptake occurs.

Original languageEnglish
Article number17040
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - Dec 1 2015

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