Turkish version of the Drug Hypersensitivity Quality of Life Questionnaire: assessment of reliability and validity

Sevim Bavbek, Seçil Kepil Özdemir, Beyza Doğanay Erdoğan, Işıl Karaboğa, Suna Büyüköztürk, Aslı Gelincik, İnsu Yılmaz, Özlem Göksel, Adile Berna Dursun, Gül Karakaya, Ali Fuat Kalyoncu, Ferhan Özşeker, Gülden Paşaoğlu Karakış, Ferda Öner Erkekol, Gözde Köycü, Metin Keren, Ilaria Baiardini, Antonino Romano

Research output: Contribution to journalArticlepeer-review


Purpose: The first disease-specific quality-of-life questionnaire in patients with drug hypersensitivity, Drug Hypersensitivity Quality of Life Questionnaire (DrHy-Q), was developed and validated recently. The aim of this study was to assess validity, reliability and responsiveness to interventions of the Turkish version of the DrHy-Q. Methods: The Turkish version of the DrHy-Q was administered to prospectively enrolled 736 patients with drug hypersensitivity from ten allergy units. To assess validity, all patients completed the validated Turkish version of Psychological General Well-Being Index (PGWBI). For test–retest reliability, 182 patients completed the DrHy-Q 1 week after the first questionnaire administration without any intervention. Responsiveness was assessed on 97 patients who had a DrHy-Q recorded at a follow-up visit after the intervention. Results: The internal consistency and test–retest reliability of the scale were adequate (Cronbach’s alpha = 0.934, intra-class correlation coefficient = 0.783). The DrHy-Q scores showed weak negative correlations with the PGWBI total and domain scores (r = − 0.378 to −0.254, p  0.05). The baseline DrHy-Q scores were significantly higher than the post-intervention scores (p = 0.008). Conclusion: The Turkish version of DrHy-Q is reliable and valid for evaluating quality of life in patients with drug hypersensitivity, and it appeared responsive to interventions.

Original languageEnglish
Pages (from-to)101-109
Number of pages9
JournalQuality of Life Research
Issue number1
Publication statusPublished - Jan 1 2016


  • Disease-specific questionnaires
  • Drug allergy
  • Drug hypersensitivity
  • Quality of life

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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