Abstract
Aim: To compare 24 h intraocular pressure (IOP) control obtained with preservative free (PF) tafluprost 0.0015% versus branded preservative containing latanoprost 0.005% administered as first choice monotherapy in patients with primary open angle glaucoma (POAG) or ocular hypertension (OHT). Methods: This prospective, observer-masked, crossover study included consecutive newly diagnosed patients with POAG or OHT, and baseline IOP between 24 and 33 mm Hg. Qualifying patients underwent baseline untreated 24 h IOP monitoring in habitual positions, with Goldmann tonometry at times 10:00, 14:00, 18:00 and 22:00, and Perkins supine tonometry at times 02:00 and 06:00. They were then randomised to either latanoprost or tafluprost, administered in the evening, for 3 months and then switched to the opposite therapy for another 3 months. 24 h monitoring was repeated at the end of each treatment period. Results: 38 patients completed the study. Mean untreated 24 h IOP (24.9 mm Hg) was significantly reduced with both prostaglandins (p
| Original language | English |
|---|---|
| Pages (from-to) | 1510-1515 |
| Number of pages | 6 |
| Journal | British Journal of Ophthalmology |
| Volume | 97 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 2013 |
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ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
Cite this
Twenty-four hour efficacy with preservative free tafluprost compared with latanoprost in patients with primary open angle glaucoma or ocular hypertension. / Konstas, Anastasios G P; Quaranta, Luciano; Katsanos, Andreas; Riva, Ivano; Tsai, James C.; Giannopoulos, Theodoros; Voudouragkaki, Irini C.; Paschalinou, Eleni; Floriani, Irene; Haidich, Anna Bettina.
In: British Journal of Ophthalmology, Vol. 97, No. 12, 12.2013, p. 1510-1515.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Twenty-four hour efficacy with preservative free tafluprost compared with latanoprost in patients with primary open angle glaucoma or ocular hypertension
AU - Konstas, Anastasios G P
AU - Quaranta, Luciano
AU - Katsanos, Andreas
AU - Riva, Ivano
AU - Tsai, James C.
AU - Giannopoulos, Theodoros
AU - Voudouragkaki, Irini C.
AU - Paschalinou, Eleni
AU - Floriani, Irene
AU - Haidich, Anna Bettina
PY - 2013/12
Y1 - 2013/12
N2 - Aim: To compare 24 h intraocular pressure (IOP) control obtained with preservative free (PF) tafluprost 0.0015% versus branded preservative containing latanoprost 0.005% administered as first choice monotherapy in patients with primary open angle glaucoma (POAG) or ocular hypertension (OHT). Methods: This prospective, observer-masked, crossover study included consecutive newly diagnosed patients with POAG or OHT, and baseline IOP between 24 and 33 mm Hg. Qualifying patients underwent baseline untreated 24 h IOP monitoring in habitual positions, with Goldmann tonometry at times 10:00, 14:00, 18:00 and 22:00, and Perkins supine tonometry at times 02:00 and 06:00. They were then randomised to either latanoprost or tafluprost, administered in the evening, for 3 months and then switched to the opposite therapy for another 3 months. 24 h monitoring was repeated at the end of each treatment period. Results: 38 patients completed the study. Mean untreated 24 h IOP (24.9 mm Hg) was significantly reduced with both prostaglandins (p
AB - Aim: To compare 24 h intraocular pressure (IOP) control obtained with preservative free (PF) tafluprost 0.0015% versus branded preservative containing latanoprost 0.005% administered as first choice monotherapy in patients with primary open angle glaucoma (POAG) or ocular hypertension (OHT). Methods: This prospective, observer-masked, crossover study included consecutive newly diagnosed patients with POAG or OHT, and baseline IOP between 24 and 33 mm Hg. Qualifying patients underwent baseline untreated 24 h IOP monitoring in habitual positions, with Goldmann tonometry at times 10:00, 14:00, 18:00 and 22:00, and Perkins supine tonometry at times 02:00 and 06:00. They were then randomised to either latanoprost or tafluprost, administered in the evening, for 3 months and then switched to the opposite therapy for another 3 months. 24 h monitoring was repeated at the end of each treatment period. Results: 38 patients completed the study. Mean untreated 24 h IOP (24.9 mm Hg) was significantly reduced with both prostaglandins (p
UR - http://www.scopus.com/inward/record.url?scp=84888640938&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84888640938&partnerID=8YFLogxK
U2 - 10.1136/bjophthalmol-2012-303026
DO - 10.1136/bjophthalmol-2012-303026
M3 - Article
C2 - 23681371
AN - SCOPUS:84888640938
VL - 97
SP - 1510
EP - 1515
JO - British Journal of Ophthalmology
JF - British Journal of Ophthalmology
SN - 0007-1161
IS - 12
ER -