Twenty-four hour efficacy with preservative free tafluprost compared with latanoprost in patients with primary open angle glaucoma or ocular hypertension

Anastasios G P Konstas, Luciano Quaranta, Andreas Katsanos, Ivano Riva, James C. Tsai, Theodoros Giannopoulos, Irini C. Voudouragkaki, Eleni Paschalinou, Irene Floriani, Anna Bettina Haidich

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Abstract

Aim: To compare 24 h intraocular pressure (IOP) control obtained with preservative free (PF) tafluprost 0.0015% versus branded preservative containing latanoprost 0.005% administered as first choice monotherapy in patients with primary open angle glaucoma (POAG) or ocular hypertension (OHT). Methods: This prospective, observer-masked, crossover study included consecutive newly diagnosed patients with POAG or OHT, and baseline IOP between 24 and 33 mm Hg. Qualifying patients underwent baseline untreated 24 h IOP monitoring in habitual positions, with Goldmann tonometry at times 10:00, 14:00, 18:00 and 22:00, and Perkins supine tonometry at times 02:00 and 06:00. They were then randomised to either latanoprost or tafluprost, administered in the evening, for 3 months and then switched to the opposite therapy for another 3 months. 24 h monitoring was repeated at the end of each treatment period. Results: 38 patients completed the study. Mean untreated 24 h IOP (24.9 mm Hg) was significantly reduced with both prostaglandins (p

Original languageEnglish
Pages (from-to)1510-1515
Number of pages6
JournalBritish Journal of Ophthalmology
Volume97
Issue number12
DOIs
Publication statusPublished - Dec 2013

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latanoprost
Ocular Hypertension
Intraocular Pressure
Manometry
Cross-Over Studies
Prostaglandins
Primary Open Angle Glaucoma
tafluprost
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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Twenty-four hour efficacy with preservative free tafluprost compared with latanoprost in patients with primary open angle glaucoma or ocular hypertension. / Konstas, Anastasios G P; Quaranta, Luciano; Katsanos, Andreas; Riva, Ivano; Tsai, James C.; Giannopoulos, Theodoros; Voudouragkaki, Irini C.; Paschalinou, Eleni; Floriani, Irene; Haidich, Anna Bettina.

In: British Journal of Ophthalmology, Vol. 97, No. 12, 12.2013, p. 1510-1515.

Research output: Contribution to journalArticle

Konstas, AGP, Quaranta, L, Katsanos, A, Riva, I, Tsai, JC, Giannopoulos, T, Voudouragkaki, IC, Paschalinou, E, Floriani, I & Haidich, AB 2013, 'Twenty-four hour efficacy with preservative free tafluprost compared with latanoprost in patients with primary open angle glaucoma or ocular hypertension', British Journal of Ophthalmology, vol. 97, no. 12, pp. 1510-1515. https://doi.org/10.1136/bjophthalmol-2012-303026
Konstas, Anastasios G P ; Quaranta, Luciano ; Katsanos, Andreas ; Riva, Ivano ; Tsai, James C. ; Giannopoulos, Theodoros ; Voudouragkaki, Irini C. ; Paschalinou, Eleni ; Floriani, Irene ; Haidich, Anna Bettina. / Twenty-four hour efficacy with preservative free tafluprost compared with latanoprost in patients with primary open angle glaucoma or ocular hypertension. In: British Journal of Ophthalmology. 2013 ; Vol. 97, No. 12. pp. 1510-1515.
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