Twenty-four hour insulin secretion and beta cell NEFA oxidation in type 2 diabetic, morbidly obese patients before and after bariatric surgery

S. Salinari, A. Bertuzzi, A. Iaconelli, M. Manco, G. Mingrone

Research output: Contribution to journalArticlepeer-review

Abstract

Aims/hypothesis: We have previously demonstrated that type 2 diabetes resolves after bariatric surgery. To study the role of NEFA in the prompt normalisation of beta cell glucose sensitivity, insulin secretion and beta cell glucose and lipid metabolism were investigated by a model of nutrient-stimulated insulin secretion using a multiple-meal test. Methods: Hourly glucose, C-peptide and NEFA were measured in nine morbidly obese, type 2 diabetic patients before and 1 week after bariatric surgery and in six matched healthy volunteers over 24 h. A mathematical model of glucose-NEFA comodulation of insulin secretion rate (ISR) was used to compute ISR and β-oxidation. Insulin sensitivity was measured by an OGTT minimal model. Results: Beta cell sensitivity to glucose and NEFA was doubled after surgery, while the 24 h insulin secretion decreased from 277.1±144.4 to 198.0±107.6 nmol/m2 (p-12 to 0.103±0.031×10 -12 mmol/min per cell, p

Original languageEnglish
Pages (from-to)1276-1284
Number of pages9
JournalDiabetologia
Volume51
Issue number7
DOIs
Publication statusPublished - Jul 2008

Keywords

  • Bariatric surgery
  • Beta cell secretion
  • Mathematical model
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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