Twist is substrate for caspase cleavage and proteasome-mediated degradation

S. Demontis, C. Rigo, S. Piccinin, M. Mizzau, M. Sonego, M. Fabris, C. Brancolini, R. Maestro

Research output: Contribution to journalArticle

Abstract

Twist is a member of the basic helix-loop-helix family of transcription factors. An aberrant Twist expression has been found in diverse types of cancer, including sarcomas, carcinomas and lymphomas, supporting a role for Twist in tumor progression. Twist is known to be essential for mesodermal development. However, since a prolonged Twist expression results in a block of muscle, cartilage and bone differentiation, Twist has to be excluded from somites during late embryogenesis for terminal differentiation to occur. This implies that Twist expression must be target of a tight control. Here we provide evidence that Twist undergoes post-transcriptional regulation. Twist is substrate for cleavage by caspases during apoptosis and its cleavage results in ubiquitin-mediated proteasome degradation. Our findings suggest that Twist post-transcriptional regulation may play an important role in tissue determination and raise the possibility that alterations in the protein turnover may account for Twist overexpression observed in tumors.

Original languageEnglish
Pages (from-to)335-345
Number of pages11
JournalCell Death and Differentiation
Volume13
Issue number2
DOIs
Publication statusPublished - Feb 2006

Keywords

  • Apoptosis
  • Caspase
  • Transcription factor
  • Twist
  • Ubiquitination

ASJC Scopus subject areas

  • Cell Biology

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    Demontis, S., Rigo, C., Piccinin, S., Mizzau, M., Sonego, M., Fabris, M., Brancolini, C., & Maestro, R. (2006). Twist is substrate for caspase cleavage and proteasome-mediated degradation. Cell Death and Differentiation, 13(2), 335-345. https://doi.org/10.1038/sj.cdd.4401744