Two cases of thymoma-associated myasthenia gravis without antibodies to the acetylcholine receptor

Research output: Contribution to journalArticle

Abstract

Thymoma-associated myasthenia gravis is considered a more severe disease compared with non-thymomatous myasthenia gravis and is generally associated with antibodies to the acetylcholine receptor (AChR-Ab). Even though a single case of thymoma-associated myasthenia gravis with anti-muscle specific kinase (MuSK) antibodies has been reported, to our knowledge, seronegative thymoma-associated myasthenia gravis has not been described. We report on two cases of this disease without antibodies to AChR or MuSK as a further evidence of the variability of myasthenia gravis in terms of antibody profile and thymic pathological findings.

Original languageEnglish
Pages (from-to)678-680
Number of pages3
JournalNeuromuscular Disorders
Volume18
Issue number8
DOIs
Publication statusPublished - Aug 2008

Fingerprint

Thymoma
Myasthenia Gravis
Cholinergic Receptors
Antibodies
Phosphotransferases
Muscles

Keywords

  • Myasthenia gravis
  • Ryanodine receptor antibodies
  • Seronegative myasthenia
  • Thymoma
  • Titin antibodies

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

Cite this

@article{238892070320439cb896f3452323308b,
title = "Two cases of thymoma-associated myasthenia gravis without antibodies to the acetylcholine receptor",
abstract = "Thymoma-associated myasthenia gravis is considered a more severe disease compared with non-thymomatous myasthenia gravis and is generally associated with antibodies to the acetylcholine receptor (AChR-Ab). Even though a single case of thymoma-associated myasthenia gravis with anti-muscle specific kinase (MuSK) antibodies has been reported, to our knowledge, seronegative thymoma-associated myasthenia gravis has not been described. We report on two cases of this disease without antibodies to AChR or MuSK as a further evidence of the variability of myasthenia gravis in terms of antibody profile and thymic pathological findings.",
keywords = "Myasthenia gravis, Ryanodine receptor antibodies, Seronegative myasthenia, Thymoma, Titin antibodies",
author = "Lorenzo Maggi and Francesca Andreetta and Carlo Antozzi and Paolo Confalonieri and Ferdinando Cornelio and Vidmer Scaioli and Renato Mantegazza",
year = "2008",
month = "8",
doi = "10.1016/j.nmd.2008.06.368",
language = "English",
volume = "18",
pages = "678--680",
journal = "Neuromuscular Disorders",
issn = "0960-8966",
publisher = "Elsevier Ltd",
number = "8",

}

TY - JOUR

T1 - Two cases of thymoma-associated myasthenia gravis without antibodies to the acetylcholine receptor

AU - Maggi, Lorenzo

AU - Andreetta, Francesca

AU - Antozzi, Carlo

AU - Confalonieri, Paolo

AU - Cornelio, Ferdinando

AU - Scaioli, Vidmer

AU - Mantegazza, Renato

PY - 2008/8

Y1 - 2008/8

N2 - Thymoma-associated myasthenia gravis is considered a more severe disease compared with non-thymomatous myasthenia gravis and is generally associated with antibodies to the acetylcholine receptor (AChR-Ab). Even though a single case of thymoma-associated myasthenia gravis with anti-muscle specific kinase (MuSK) antibodies has been reported, to our knowledge, seronegative thymoma-associated myasthenia gravis has not been described. We report on two cases of this disease without antibodies to AChR or MuSK as a further evidence of the variability of myasthenia gravis in terms of antibody profile and thymic pathological findings.

AB - Thymoma-associated myasthenia gravis is considered a more severe disease compared with non-thymomatous myasthenia gravis and is generally associated with antibodies to the acetylcholine receptor (AChR-Ab). Even though a single case of thymoma-associated myasthenia gravis with anti-muscle specific kinase (MuSK) antibodies has been reported, to our knowledge, seronegative thymoma-associated myasthenia gravis has not been described. We report on two cases of this disease without antibodies to AChR or MuSK as a further evidence of the variability of myasthenia gravis in terms of antibody profile and thymic pathological findings.

KW - Myasthenia gravis

KW - Ryanodine receptor antibodies

KW - Seronegative myasthenia

KW - Thymoma

KW - Titin antibodies

UR - http://www.scopus.com/inward/record.url?scp=48549100777&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=48549100777&partnerID=8YFLogxK

U2 - 10.1016/j.nmd.2008.06.368

DO - 10.1016/j.nmd.2008.06.368

M3 - Article

C2 - 18657424

AN - SCOPUS:48549100777

VL - 18

SP - 678

EP - 680

JO - Neuromuscular Disorders

JF - Neuromuscular Disorders

SN - 0960-8966

IS - 8

ER -