Two different hypofractionated breast radiotherapy schedules for 113 patients with ductal carcinoma in situ: Preliminary results

Marina Guenzi, Flavio Giannelli, Davide Bosetti, Gladys Blandino, Maria Letizia Milanese, Francesco Pupillo, Renzo Corvo, Alessandra Fozza

Research output: Contribution to journalArticle

Abstract

Aim: To assess local control and cosmetic outcomes for two different hypofractionated radiotherapy schedules after breast-conserving surgery for ductal carcinoma in situ (DCIS). Patients and Methods: A total of 113 breast-conserving operated patients with DCIS were treated from August 2006 to August 2011: 41 women received 46 Gy in 20 fractions of 2.3 Gy four times a week, for five weeks; the other 72 patients received 39 Gy in 13 fractions of 3 Gy four times a week for 3.5 weeks. Both schedules involved a concomitant boost to the tumor bed, with dose adjustment according to the surgical margins. Results: The median follow-up is 30.5 months. Overall, the treatments were well-tolerated. The most common acute effect was erythema: grade 1 in 56.1% and 31.9% in the longer and in the shorter hypofractionated treatment, grade 2 in 9.8% and 0% of cases respectively. Late toxicity of fibrosis occurred at grade 1 in 19.6% and 15.3% respectively and at grade 2 in 0% and 2.8%. Conclusion: These results suggest that patients with DCIS can be safely treated with a shorter radiotherapy regimen.

Original languageEnglish
Pages (from-to)3503-3508
Number of pages6
JournalAnticancer Research
Volume33
Issue number8
Publication statusPublished - Aug 2013

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Carcinoma, Intraductal, Noninfiltrating
Appointments and Schedules
Breast
Radiotherapy
Segmental Mastectomy
Erythema
Cosmetics
Fibrosis
Therapeutics
Neoplasms

Keywords

  • Breast cancer
  • Ductal carcinoma in situ
  • Hypofractionated radiotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Guenzi, M., Giannelli, F., Bosetti, D., Blandino, G., Milanese, M. L., Pupillo, F., ... Fozza, A. (2013). Two different hypofractionated breast radiotherapy schedules for 113 patients with ductal carcinoma in situ: Preliminary results. Anticancer Research, 33(8), 3503-3508.

Two different hypofractionated breast radiotherapy schedules for 113 patients with ductal carcinoma in situ : Preliminary results. / Guenzi, Marina; Giannelli, Flavio; Bosetti, Davide; Blandino, Gladys; Milanese, Maria Letizia; Pupillo, Francesco; Corvo, Renzo; Fozza, Alessandra.

In: Anticancer Research, Vol. 33, No. 8, 08.2013, p. 3503-3508.

Research output: Contribution to journalArticle

Guenzi, M, Giannelli, F, Bosetti, D, Blandino, G, Milanese, ML, Pupillo, F, Corvo, R & Fozza, A 2013, 'Two different hypofractionated breast radiotherapy schedules for 113 patients with ductal carcinoma in situ: Preliminary results', Anticancer Research, vol. 33, no. 8, pp. 3503-3508.
Guenzi, Marina ; Giannelli, Flavio ; Bosetti, Davide ; Blandino, Gladys ; Milanese, Maria Letizia ; Pupillo, Francesco ; Corvo, Renzo ; Fozza, Alessandra. / Two different hypofractionated breast radiotherapy schedules for 113 patients with ductal carcinoma in situ : Preliminary results. In: Anticancer Research. 2013 ; Vol. 33, No. 8. pp. 3503-3508.
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