Two-dimensional neovascular complexity is significantly higher in nontumor prostate tissue than in low-risk prostate cancer

Gianluigi Taverna, Fabio Grizzi, Piergiuseppe Colombo, Mauro Seveso, Guido Giusti, Silvia Proietti, Girolamo Fiorini, Giovanni Lughezzani, Paolo Casale, Nicolò Buffi, Massimo Lazzari, Giorgio Guazzoni

Research output: Contribution to journalArticle

Abstract

Purpose: Prostate cancer is the most frequent cancer in men in Europe. A major focus in urology is the identification of new biomarkers with improved accuracy in patients with low-risk prostate cancer. Here, we evaluated two-dimensional neovascular complexity in prostate tumor and nontumor biopsy cores by use of a computer-aided image analysis system and assessed the correlations between the results and selected clinical and pathological parameters of prostate carcinoma. Materials and Methods: A total of 280 prostate biopsy sections from a homogeneous series of 70 patients with low-risk prostate cancer (Gleason score 3+3, prostate-specific antigen [PSA]

Original languageEnglish
Pages (from-to)435-442
Number of pages8
JournalKorean Journal of Urology
Volume56
Issue number6
DOIs
Publication statusPublished - 2015

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Keywords

  • Biological markers
  • Blood vessels
  • Neoplasms
  • Prostate

ASJC Scopus subject areas

  • Urology

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