Two episodes of ifosfamide-related neurotoxicity in the same patient following different schedules and doses of the drug. A case report

A. Comandone, W. Liboni, P. Picci, C. Oliva, P. Pignatta, O. Dal Canton, P. Bergnolo, S. Chiadò Cutin, A. Boglione

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Abstract

We report the first case of recurrent ifosfamide-related neurotoxicity in the same patient following two distinct administrations of the drug at different doses and schedules and with a long interval between the two episodes. Remarkably, the first event was characterized by confusion and hallucinations, while the second, 29 months later, was characterized by partial and generalized seizures. Between the two episodes the patient had received high-dose cyclophosphamide, an oxazophoshorine agent closely related to ifosfamide, without any neurological side effects. We briefly discuss the diagnosis and management of ifosfamide-related encephalopathy.

Original languageEnglish
Pages (from-to)483-486
Number of pages4
JournalTumori
Volume86
Issue number6
Publication statusPublished - 2000

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Keywords

  • Chemotherapy
  • Ifosfamide
  • Neurotoxicity

ASJC Scopus subject areas

  • Cancer Research

Cite this

Comandone, A., Liboni, W., Picci, P., Oliva, C., Pignatta, P., Dal Canton, O., Bergnolo, P., Chiadò Cutin, S., & Boglione, A. (2000). Two episodes of ifosfamide-related neurotoxicity in the same patient following different schedules and doses of the drug. A case report. Tumori, 86(6), 483-486.