Due tipi di interazione degli anticorpi piastrino-reattivi nella porpora trombocitopenica immune in pediatria

Translated title of the contribution: Two modalities by which platelet-reactive antibodies interact with platelets in childhood immune thrombocytopenic purpura

P. Biglino, P. Perutelli, C. Dufour, P. G. Mori

Research output: Contribution to journalArticle

Abstract

Immune thrombocytopenic purpura (ITP) is characterized by increased platelet destruction mediated by platelet-reactive antibodies. Pediatric ITP occurs as an acute disorder (a-ITP) or as a chronic disease (c-ITP). The autoimmune nature of c-ITP is widely accepted; on the other hand, different mechanisms of platelet destruction have been proposed to explain the immunopathogenesis of a-ITP. We investigated antiplatelet antibodies in 337 serum samples from ITP patients, using a cytoadherence test (SPRCA) and an immunofluorescence one (PSIFT), and analyzed antibody-platelet membrane interaction. Platelet-reactive antibodies were detected in 55.8% of cases. In c-ITP at onset we only found specific autoantibodies (F(ab′)2-mediated binding); in a-ITP a similar frequence of autoantibodies and Fc-bound immunoglobulins (aspecific antibodies, immune complexes) was detected. Our results are in keeping with the autoimmune nature of c-ITP; however, in a-ITP it appears that two different immunologic mechanisms (autoantibody- and immune complex-mediated) may be responsible for thrombocytopenia. In remission, we did not find antiplatelet antibodies in a-ITP patients, but we detected them in some c-ITP patients: these latter may be at risk for relapse in spite of their long-term remission.

Original languageItalian
Pages (from-to)773-777
Number of pages5
JournalRivista Italiana di Pediatria
Volume22
Issue number5
Publication statusPublished - 1996

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Idiopathic Thrombocytopenic Purpura
Blood Platelets
Antibodies
Autoantibodies
Antigen-Antibody Complex
Immunoglobulin Fc Fragments
Thrombocytopenia
Fluorescent Antibody Technique
Chronic Disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Due tipi di interazione degli anticorpi piastrino-reattivi nella porpora trombocitopenica immune in pediatria. / Biglino, P.; Perutelli, P.; Dufour, C.; Mori, P. G.

In: Rivista Italiana di Pediatria, Vol. 22, No. 5, 1996, p. 773-777.

Research output: Contribution to journalArticle

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