Two patients with COMT inhibitor-induced hepatic dysfunction and UGT1A9 genetic polymorphism

E. Martignoni, M. Cosentino, M. Ferrari, G. Porta, E. Mattarucchi, F. Marino, S. Lecchini, G. Nappi

Research output: Contribution to journalArticle

Abstract

The authors report two cases of catechol-O-methyltransferase (COMT) inhibitor-induced asymptomatic hepatic dysfunction in women with Parkinson disease. The patients were genotyped for the UDP-glucuronosyltransferase (UGT) 1A9 gene (which encodes the main COMT inhibitor-metabolizing enzyme), and found to carry mutations leading to defective glucuronidation activity. This suggests that UGT1A9 poor metabolizer genotype(s) may be a predisposing factor for COMT inhibitor-induced hepatotoxicity.

Original languageEnglish
Pages (from-to)1820-1822
Number of pages3
JournalNeurology
Volume65
Issue number11
DOIs
Publication statusPublished - Dec 2005

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Genetic Polymorphisms
Liver
Causality
Parkinson Disease
Genotype
Mutation
Enzymes
Genes
Catechol O-Methyltransferase Inhibitors

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Martignoni, E., Cosentino, M., Ferrari, M., Porta, G., Mattarucchi, E., Marino, F., ... Nappi, G. (2005). Two patients with COMT inhibitor-induced hepatic dysfunction and UGT1A9 genetic polymorphism. Neurology, 65(11), 1820-1822. https://doi.org/10.1212/01.wnl.0000187066.81162.70

Two patients with COMT inhibitor-induced hepatic dysfunction and UGT1A9 genetic polymorphism. / Martignoni, E.; Cosentino, M.; Ferrari, M.; Porta, G.; Mattarucchi, E.; Marino, F.; Lecchini, S.; Nappi, G.

In: Neurology, Vol. 65, No. 11, 12.2005, p. 1820-1822.

Research output: Contribution to journalArticle

Martignoni, E, Cosentino, M, Ferrari, M, Porta, G, Mattarucchi, E, Marino, F, Lecchini, S & Nappi, G 2005, 'Two patients with COMT inhibitor-induced hepatic dysfunction and UGT1A9 genetic polymorphism', Neurology, vol. 65, no. 11, pp. 1820-1822. https://doi.org/10.1212/01.wnl.0000187066.81162.70
Martignoni E, Cosentino M, Ferrari M, Porta G, Mattarucchi E, Marino F et al. Two patients with COMT inhibitor-induced hepatic dysfunction and UGT1A9 genetic polymorphism. Neurology. 2005 Dec;65(11):1820-1822. https://doi.org/10.1212/01.wnl.0000187066.81162.70
Martignoni, E. ; Cosentino, M. ; Ferrari, M. ; Porta, G. ; Mattarucchi, E. ; Marino, F. ; Lecchini, S. ; Nappi, G. / Two patients with COMT inhibitor-induced hepatic dysfunction and UGT1A9 genetic polymorphism. In: Neurology. 2005 ; Vol. 65, No. 11. pp. 1820-1822.
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