Abstract
The authors report two cases of catechol-O-methyltransferase (COMT) inhibitor-induced asymptomatic hepatic dysfunction in women with Parkinson disease. The patients were genotyped for the UDP-glucuronosyltransferase (UGT) 1A9 gene (which encodes the main COMT inhibitor-metabolizing enzyme), and found to carry mutations leading to defective glucuronidation activity. This suggests that UGT1A9 poor metabolizer genotype(s) may be a predisposing factor for COMT inhibitor-induced hepatotoxicity.
Original language | English |
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Pages (from-to) | 1820-1822 |
Number of pages | 3 |
Journal | Neurology |
Volume | 65 |
Issue number | 11 |
DOIs | |
Publication status | Published - Dec 2005 |
ASJC Scopus subject areas
- Neuroscience(all)