Two patients with COMT inhibitor-induced hepatic dysfunction and UGT1A9 genetic polymorphism

E. Martignoni, M. Cosentino, M. Ferrari, G. Porta, E. Mattarucchi, F. Marino, S. Lecchini, G. Nappi

Research output: Contribution to journalArticlepeer-review

Abstract

The authors report two cases of catechol-O-methyltransferase (COMT) inhibitor-induced asymptomatic hepatic dysfunction in women with Parkinson disease. The patients were genotyped for the UDP-glucuronosyltransferase (UGT) 1A9 gene (which encodes the main COMT inhibitor-metabolizing enzyme), and found to carry mutations leading to defective glucuronidation activity. This suggests that UGT1A9 poor metabolizer genotype(s) may be a predisposing factor for COMT inhibitor-induced hepatotoxicity.

Original languageEnglish
Pages (from-to)1820-1822
Number of pages3
JournalNeurology
Volume65
Issue number11
DOIs
Publication statusPublished - Dec 2005

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Two patients with COMT inhibitor-induced hepatic dysfunction and UGT1A9 genetic polymorphism'. Together they form a unique fingerprint.

Cite this