Abstract
The authors report two cases of catechol-O-methyltransferase (COMT) inhibitor-induced asymptomatic hepatic dysfunction in women with Parkinson disease. The patients were genotyped for the UDP-glucuronosyltransferase (UGT) 1A9 gene (which encodes the main COMT inhibitor-metabolizing enzyme), and found to carry mutations leading to defective glucuronidation activity. This suggests that UGT1A9 poor metabolizer genotype(s) may be a predisposing factor for COMT inhibitor-induced hepatotoxicity.
| Original language | English |
|---|---|
| Pages (from-to) | 1820-1822 |
| Number of pages | 3 |
| Journal | Neurology |
| Volume | 65 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Dec 2005 |
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ASJC Scopus subject areas
- Neuroscience(all)
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Two patients with COMT inhibitor-induced hepatic dysfunction and UGT1A9 genetic polymorphism. / Martignoni, E.; Cosentino, M.; Ferrari, M.; Porta, G.; Mattarucchi, E.; Marino, F.; Lecchini, S.; Nappi, G.
In: Neurology, Vol. 65, No. 11, 12.2005, p. 1820-1822.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Two patients with COMT inhibitor-induced hepatic dysfunction and UGT1A9 genetic polymorphism
AU - Martignoni, E.
AU - Cosentino, M.
AU - Ferrari, M.
AU - Porta, G.
AU - Mattarucchi, E.
AU - Marino, F.
AU - Lecchini, S.
AU - Nappi, G.
PY - 2005/12
Y1 - 2005/12
N2 - The authors report two cases of catechol-O-methyltransferase (COMT) inhibitor-induced asymptomatic hepatic dysfunction in women with Parkinson disease. The patients were genotyped for the UDP-glucuronosyltransferase (UGT) 1A9 gene (which encodes the main COMT inhibitor-metabolizing enzyme), and found to carry mutations leading to defective glucuronidation activity. This suggests that UGT1A9 poor metabolizer genotype(s) may be a predisposing factor for COMT inhibitor-induced hepatotoxicity.
AB - The authors report two cases of catechol-O-methyltransferase (COMT) inhibitor-induced asymptomatic hepatic dysfunction in women with Parkinson disease. The patients were genotyped for the UDP-glucuronosyltransferase (UGT) 1A9 gene (which encodes the main COMT inhibitor-metabolizing enzyme), and found to carry mutations leading to defective glucuronidation activity. This suggests that UGT1A9 poor metabolizer genotype(s) may be a predisposing factor for COMT inhibitor-induced hepatotoxicity.
UR - http://www.scopus.com/inward/record.url?scp=33645094707&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645094707&partnerID=8YFLogxK
U2 - 10.1212/01.wnl.0000187066.81162.70
DO - 10.1212/01.wnl.0000187066.81162.70
M3 - Article
C2 - 16344532
AN - SCOPUS:33645094707
VL - 65
SP - 1820
EP - 1822
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 11
ER -