Two pregnancies shortly after transplantation with reduced intensity conditioning in chronic myeloid leukemia

Maura Faraci, Susanne Matthes-Martin, Edoardo Lanino, Giuseppe Morreale, Marta Ferretti, Stefano Giardino, Concetta Micalizzi, Adriana Balduzzi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

POI is a relevant late complication after HSCT and occurring more frequently after MAC than after RIC regimens. Reports on the frequency of POI after RIC in a large pediatric and adolescent population are lacking. In this study, we describe a girl affected by CML diagnosed at the age of 15 yr and treated with oncarbide and interferon followed by imatinib and dasatinib. She had two pregnancies shortly after RIC performed according to the CML-SCT I-BFM protocol including TT, FLU, and MEL. Hypergonadotropic hypogonadism occurred four months after HSCT; menstruations resumed regularly six months after HSCT. Eight and 20 months after HSCT, the patient became pregnant and then delivered, respectively, two babies at term by cesarean section. Both newborns had no neonatal complications. Donor chimerism at time of two pregnancies and five yr after transplantation demonstrated complete donor engraftment. These findings suggest that I-BFM CML-SCT protocol could be a promising treatment option for adolescents or young adults with CML eligible for HSCT.

Original languageEnglish
Pages (from-to)158-161
Number of pages4
JournalPediatric Transplantation
Volume20
Issue number1
DOIs
Publication statusPublished - Feb 1 2016

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Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Transplantation
Tissue Donors
Pregnancy
Chimerism
Hypogonadism
Menstruation
Cesarean Section
Interferons
Young Adult
Newborn Infant
Pediatrics
Population
Therapeutics
caN protocol
PVDA protocol
Dasatinib
Imatinib Mesylate

Keywords

  • chronic myeloid leukemia
  • premature ovarian insufficiency
  • reduced intensity conditioning regimen

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Cite this

Two pregnancies shortly after transplantation with reduced intensity conditioning in chronic myeloid leukemia. / Faraci, Maura; Matthes-Martin, Susanne; Lanino, Edoardo; Morreale, Giuseppe; Ferretti, Marta; Giardino, Stefano; Micalizzi, Concetta; Balduzzi, Adriana.

In: Pediatric Transplantation, Vol. 20, No. 1, 01.02.2016, p. 158-161.

Research output: Contribution to journalArticle

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AU - Giardino, Stefano

AU - Micalizzi, Concetta

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