Abstract
POI is a relevant late complication after HSCT and occurring more frequently after MAC than after RIC regimens. Reports on the frequency of POI after RIC in a large pediatric and adolescent population are lacking. In this study, we describe a girl affected by CML diagnosed at the age of 15 yr and treated with oncarbide and interferon followed by imatinib and dasatinib. She had two pregnancies shortly after RIC performed according to the CML-SCT I-BFM protocol including TT, FLU, and MEL. Hypergonadotropic hypogonadism occurred four months after HSCT; menstruations resumed regularly six months after HSCT. Eight and 20 months after HSCT, the patient became pregnant and then delivered, respectively, two babies at term by cesarean section. Both newborns had no neonatal complications. Donor chimerism at time of two pregnancies and five yr after transplantation demonstrated complete donor engraftment. These findings suggest that I-BFM CML-SCT protocol could be a promising treatment option for adolescents or young adults with CML eligible for HSCT.
| Original language | English |
|---|---|
| Pages (from-to) | 158-161 |
| Number of pages | 4 |
| Journal | Pediatric Transplantation |
| Volume | 20 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 1 2016 |
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Keywords
- chronic myeloid leukemia
- premature ovarian insufficiency
- reduced intensity conditioning regimen
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Transplantation
Cite this
Two pregnancies shortly after transplantation with reduced intensity conditioning in chronic myeloid leukemia. / Faraci, Maura; Matthes-Martin, Susanne; Lanino, Edoardo; Morreale, Giuseppe; Ferretti, Marta; Giardino, Stefano; Micalizzi, Concetta; Balduzzi, Adriana.
In: Pediatric Transplantation, Vol. 20, No. 1, 01.02.2016, p. 158-161.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Two pregnancies shortly after transplantation with reduced intensity conditioning in chronic myeloid leukemia
AU - Faraci, Maura
AU - Matthes-Martin, Susanne
AU - Lanino, Edoardo
AU - Morreale, Giuseppe
AU - Ferretti, Marta
AU - Giardino, Stefano
AU - Micalizzi, Concetta
AU - Balduzzi, Adriana
PY - 2016/2/1
Y1 - 2016/2/1
N2 - POI is a relevant late complication after HSCT and occurring more frequently after MAC than after RIC regimens. Reports on the frequency of POI after RIC in a large pediatric and adolescent population are lacking. In this study, we describe a girl affected by CML diagnosed at the age of 15 yr and treated with oncarbide and interferon followed by imatinib and dasatinib. She had two pregnancies shortly after RIC performed according to the CML-SCT I-BFM protocol including TT, FLU, and MEL. Hypergonadotropic hypogonadism occurred four months after HSCT; menstruations resumed regularly six months after HSCT. Eight and 20 months after HSCT, the patient became pregnant and then delivered, respectively, two babies at term by cesarean section. Both newborns had no neonatal complications. Donor chimerism at time of two pregnancies and five yr after transplantation demonstrated complete donor engraftment. These findings suggest that I-BFM CML-SCT protocol could be a promising treatment option for adolescents or young adults with CML eligible for HSCT.
AB - POI is a relevant late complication after HSCT and occurring more frequently after MAC than after RIC regimens. Reports on the frequency of POI after RIC in a large pediatric and adolescent population are lacking. In this study, we describe a girl affected by CML diagnosed at the age of 15 yr and treated with oncarbide and interferon followed by imatinib and dasatinib. She had two pregnancies shortly after RIC performed according to the CML-SCT I-BFM protocol including TT, FLU, and MEL. Hypergonadotropic hypogonadism occurred four months after HSCT; menstruations resumed regularly six months after HSCT. Eight and 20 months after HSCT, the patient became pregnant and then delivered, respectively, two babies at term by cesarean section. Both newborns had no neonatal complications. Donor chimerism at time of two pregnancies and five yr after transplantation demonstrated complete donor engraftment. These findings suggest that I-BFM CML-SCT protocol could be a promising treatment option for adolescents or young adults with CML eligible for HSCT.
KW - chronic myeloid leukemia
KW - premature ovarian insufficiency
KW - reduced intensity conditioning regimen
UR - http://www.scopus.com/inward/record.url?scp=84960853378&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84960853378&partnerID=8YFLogxK
U2 - 10.1111/petr.12630
DO - 10.1111/petr.12630
M3 - Article
AN - SCOPUS:84960853378
VL - 20
SP - 158
EP - 161
JO - Pediatric Transplantation
JF - Pediatric Transplantation
SN - 1397-3142
IS - 1
ER -