Two subtypes of enteric non-opioid σ receptors in guinea-pig cholinergic motor neurons

Teresa Coccini, Lucio G. Costa, Luigi Manzo, Stefano M. Candura, Nerio Iapadre, Barbara Balestra, Marcello Tonini

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

In the longitudinal muscle-myenteric plexus preparation (LMMP) of the guinea-pig ileum, the non-opioid σ receptors agonists, 1,3-di-ortho-tolylguanidine (DTG) and (+)N-allyl-N-normetazocine [(+)SKF 10,047], had opposite effects on nerve-mediated cholinergic contractions caused by electrical field stimulation. DTG (0.1-10 μM) inhibited and (+)SKF 10,047 (0.1-10 μM) markedly enhanced these contractile responses. Both effects were evaluated in the presence (0.5 or 1 μM) of the putative antagonists at central σ sites: haloperidol, rimcazole, BMY 14802 and dextromethorphan. Haloperidol and dextromethorphan were ineffective. Rimcazole antagonized the effect of both DTG and (+)SKF 10.047. BMY 14802 antagonized the (+)SKF 10,047-mediated excitatory response only. These results suggest that two σ receptor subtypes are present in enteric cholinergic motor neurons innervating the longitudinal coat. Rimcazole and BMY 14802 may provide useful tools for the characterization of peripheral non-opioid σ receptors.

Original languageEnglish
Pages (from-to)105-108
Number of pages4
JournalEuropean Journal of Pharmacology
Volume198
Issue number1
DOIs
Publication statusPublished - May 30 1991

Fingerprint

Cholinergic Neurons
Motor Neurons
Dextromethorphan
Guinea Pigs
Haloperidol
Myenteric Plexus
Ileum
Cholinergic Agents
Electric Stimulation
Muscles
rimcazole
alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol

Keywords

  • (+)-SK&F 10,047 ((+)-N-allyl-N-normetazocine)
  • (Guinea-pig)
  • BMY 14802
  • Dextromethorphan
  • DTG (1,3-di-ortho-tolylguanidine)
  • Enteric cholinergic nerves
  • Haloperidol
  • Rimcazole
  • σ Receptors

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Two subtypes of enteric non-opioid σ receptors in guinea-pig cholinergic motor neurons. / Coccini, Teresa; Costa, Lucio G.; Manzo, Luigi; Candura, Stefano M.; Iapadre, Nerio; Balestra, Barbara; Tonini, Marcello.

In: European Journal of Pharmacology, Vol. 198, No. 1, 30.05.1991, p. 105-108.

Research output: Contribution to journalArticle

Coccini, Teresa ; Costa, Lucio G. ; Manzo, Luigi ; Candura, Stefano M. ; Iapadre, Nerio ; Balestra, Barbara ; Tonini, Marcello. / Two subtypes of enteric non-opioid σ receptors in guinea-pig cholinergic motor neurons. In: European Journal of Pharmacology. 1991 ; Vol. 198, No. 1. pp. 105-108.
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