Two-to-one AV block associated with the congenital long QT syndrome

Etienne Pruvot, Antoine De Torrente, Gaetano M. De Ferrari, Peter J. Schwartz, Jean Jacques Goy

Research output: Contribution to journalArticlepeer-review


Introduction: Conduction abnormalities associated with long QT syndrome (LQTS) have been reported as 'pseudo 2:1 AV block' due to sinus intervals shorter than ventricular refractoriness. Method and Results: We report the electrophysiologic characteristics of a patient suffering from congenital LQTS with episodes of true 2:1 AV block. Induction of 2:1 infra-Hisian blocks and return to 1:1 conduction were observed using single atrial and ventricular extrastimuli. The block was located in the Purkinje network but not in the myocardium. Conclusion: The His-Purkinje system of our LQTS patient displayed dynamic properties with a strong increase in refractoriness for short-long sequences and a decrease for long-short sequences that triggered intermittent 2:1 AV blocks.

Original languageEnglish
Pages (from-to)108-113
Number of pages6
JournalJournal of Cardiovascular Electrophysiology
Issue number1
Publication statusPublished - 1999


  • AV block
  • Electrophysiologic study
  • His-Purkinje system
  • Left cardiac sympathetic denervation
  • LQTS
  • Refractory period

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine


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