Two to Tango: Regulation of Mammalian Iron Metabolism

Matthias W. Hentze, Martina U. Muckenthaler, Bruno Galy, Clara Camaschella

Research output: Contribution to journalArticle

Abstract

Disruptions in iron homeostasis from both iron deficiency and overload account for some of the most common human diseases. Iron metabolism is balanced by two regulatory systems, one that functions systemically and relies on the hormone hepcidin and the iron exporter ferroportin, and another that predominantly controls cellular iron metabolism through iron-regulatory proteins that bind iron-responsive elements in regulated messenger RNAs. We describe how the two distinct systems function and how they " tango" together in a coordinated manner. We also highlight some of the current questions in mammalian iron metabolism and discuss therapeutic opportunities arising from a better understanding of the underlying biological principles.

Original languageEnglish
Pages (from-to)24-38
Number of pages15
JournalCell
Volume142
Issue number1
DOIs
Publication statusPublished - Jul 2010

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Hentze, M. W., Muckenthaler, M. U., Galy, B., & Camaschella, C. (2010). Two to Tango: Regulation of Mammalian Iron Metabolism. Cell, 142(1), 24-38. https://doi.org/10.1016/j.cell.2010.06.028