Abstract
The term diaschisis refers to a neural dysfunction manifesting in anatomically intact, but functionally related, brain regions distant from a primary lesion. Here we report the diaschisis phenomenon as a consequence of a first demyelinating event in the middle and superior cerebellar peduncles in both the ipsilateral cerebellar hemisphere and in the contralateral thalamus and cerebral cortex (two-way crossed cerebellar diaschisis), resulting in the simultaneous disruption of the afferent cortico-ponto-cerebellar pathway and the efferent cerebellar-thalamo-cortical pathway. The use of 18F-FDG-PET could help clarifying in vivo the distant pathophysiological effect of focal lesions in inflammatory diseases such as multiple sclerosis.
| Original language | English |
|---|---|
| Pages (from-to) | 225-226 |
| Number of pages | 2 |
| Journal | The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.. |
| Volume | 63 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jun 1 2019 |
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ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Two-way crossed cerebellar diaschisis in a clinically isolated syndrome suggestive of multiple sclerosis. / Boffa, Giacomo; Lapucci, Caterina; Morbelli, Silvia D.; Nobili, Flavio M.
In: The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.., Vol. 63, No. 2, 01.06.2019, p. 225-226.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Two-way crossed cerebellar diaschisis in a clinically isolated syndrome suggestive of multiple sclerosis
AU - Boffa, Giacomo
AU - Lapucci, Caterina
AU - Morbelli, Silvia D.
AU - Nobili, Flavio M.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - The term diaschisis refers to a neural dysfunction manifesting in anatomically intact, but functionally related, brain regions distant from a primary lesion. Here we report the diaschisis phenomenon as a consequence of a first demyelinating event in the middle and superior cerebellar peduncles in both the ipsilateral cerebellar hemisphere and in the contralateral thalamus and cerebral cortex (two-way crossed cerebellar diaschisis), resulting in the simultaneous disruption of the afferent cortico-ponto-cerebellar pathway and the efferent cerebellar-thalamo-cortical pathway. The use of 18F-FDG-PET could help clarifying in vivo the distant pathophysiological effect of focal lesions in inflammatory diseases such as multiple sclerosis.
AB - The term diaschisis refers to a neural dysfunction manifesting in anatomically intact, but functionally related, brain regions distant from a primary lesion. Here we report the diaschisis phenomenon as a consequence of a first demyelinating event in the middle and superior cerebellar peduncles in both the ipsilateral cerebellar hemisphere and in the contralateral thalamus and cerebral cortex (two-way crossed cerebellar diaschisis), resulting in the simultaneous disruption of the afferent cortico-ponto-cerebellar pathway and the efferent cerebellar-thalamo-cortical pathway. The use of 18F-FDG-PET could help clarifying in vivo the distant pathophysiological effect of focal lesions in inflammatory diseases such as multiple sclerosis.
UR - http://www.scopus.com/inward/record.url?scp=85072508651&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85072508651&partnerID=8YFLogxK
U2 - 10.23736/S1824-4785.19.03171-6
DO - 10.23736/S1824-4785.19.03171-6
M3 - Article
C2 - 31089076
AN - SCOPUS:85072508651
VL - 63
SP - 225
EP - 226
JO - Quarterly Journal of Nuclear Medicine and Molecular Imaging
JF - Quarterly Journal of Nuclear Medicine and Molecular Imaging
SN - 1824-4785
IS - 2
ER -