Abstract
The pharmacokinetic properties of immunosuppressive drugs are quite different in newborns than in adults and few studies describe the pharmacokinetics of these drugs in pediatric heart transplant recipients. We report on the two-year follow up of a neonate who underwent heart transplantation for Hypoplastic Left Heart Syndrome on day of life 9. Two different immunosuppressive regimens were used: cyclosporine, azathioprine and prednisone in the early postoperative period, followed by the routine tacrolimus and mycophenolate mofetil combination plus prednisone from post-transplant day 22. Our findings demonstrate marked variability in immunosuppressive pharmacokinetic profiles early post-transplant. Frequent monitoring of drug levels is required to ensure that they remain within the therapeutic range. After the first 23 months post-transplant, changes in immunosuppressive drug levels are less marked and correlate more with the administered dosage.
| Original language | English |
|---|---|
| Pages (from-to) | 108-110 |
| Number of pages | 3 |
| Journal | Journal of Maternal-Fetal and Neonatal Medicine |
| Volume | 22 |
| Issue number | SUPPL. 3 |
| DOIs | |
| Publication status | Published - 2009 |
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Keywords
- Follow-up
- Heart transplantation
- Immunosuppressive drugs
- Newborn
- Pharmacokinetics
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Obstetrics and Gynaecology
Cite this
Two-year follow-up of the pharmacokinetics of immunosuppressive drugs in a neonate who underwent heart transplantation. / Regazzi, Mario; Perotti, Gianfranco; Pellegrini, Carlo; Molinaro, Maria Delfina; Tzialla, Chryssoula; Cabano, Rita; D'Armini, Andrea Maria; Stronati, Mauro; Viganó, Mario.
In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 22, No. SUPPL. 3, 2009, p. 108-110.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Two-year follow-up of the pharmacokinetics of immunosuppressive drugs in a neonate who underwent heart transplantation
AU - Regazzi, Mario
AU - Perotti, Gianfranco
AU - Pellegrini, Carlo
AU - Molinaro, Maria Delfina
AU - Tzialla, Chryssoula
AU - Cabano, Rita
AU - D'Armini, Andrea Maria
AU - Stronati, Mauro
AU - Viganó, Mario
PY - 2009
Y1 - 2009
N2 - The pharmacokinetic properties of immunosuppressive drugs are quite different in newborns than in adults and few studies describe the pharmacokinetics of these drugs in pediatric heart transplant recipients. We report on the two-year follow up of a neonate who underwent heart transplantation for Hypoplastic Left Heart Syndrome on day of life 9. Two different immunosuppressive regimens were used: cyclosporine, azathioprine and prednisone in the early postoperative period, followed by the routine tacrolimus and mycophenolate mofetil combination plus prednisone from post-transplant day 22. Our findings demonstrate marked variability in immunosuppressive pharmacokinetic profiles early post-transplant. Frequent monitoring of drug levels is required to ensure that they remain within the therapeutic range. After the first 23 months post-transplant, changes in immunosuppressive drug levels are less marked and correlate more with the administered dosage.
AB - The pharmacokinetic properties of immunosuppressive drugs are quite different in newborns than in adults and few studies describe the pharmacokinetics of these drugs in pediatric heart transplant recipients. We report on the two-year follow up of a neonate who underwent heart transplantation for Hypoplastic Left Heart Syndrome on day of life 9. Two different immunosuppressive regimens were used: cyclosporine, azathioprine and prednisone in the early postoperative period, followed by the routine tacrolimus and mycophenolate mofetil combination plus prednisone from post-transplant day 22. Our findings demonstrate marked variability in immunosuppressive pharmacokinetic profiles early post-transplant. Frequent monitoring of drug levels is required to ensure that they remain within the therapeutic range. After the first 23 months post-transplant, changes in immunosuppressive drug levels are less marked and correlate more with the administered dosage.
KW - Follow-up
KW - Heart transplantation
KW - Immunosuppressive drugs
KW - Newborn
KW - Pharmacokinetics
UR - http://www.scopus.com/inward/record.url?scp=70449372585&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70449372585&partnerID=8YFLogxK
U2 - 10.1080/14767050903181278
DO - 10.1080/14767050903181278
M3 - Article
C2 - 19925370
AN - SCOPUS:70449372585
VL - 22
SP - 108
EP - 110
JO - Journal of Maternal-Fetal and Neonatal Medicine
JF - Journal of Maternal-Fetal and Neonatal Medicine
SN - 1476-7058
IS - SUPPL. 3
ER -