Two-Year Longitudinal Monitoring of Amnestic Mild Cognitive Impairment Patients with Prodromal Alzheimer's Disease Using Topographical Biomarkers Derived from Functional Magnetic Resonance Imaging and Electroencephalographic Activity

J. Jovicich, C. Babiloni, C. Ferrari, M. Marizzoni, D. V. Moretti, C. Del Percio, R. Lizio, S. Lopez, S. Galluzzi, D. Albani, L. Cavaliere, L. Minati, M. Didic, U. Fiedler, G. Forloni, T. Hensch, J. L. Molinuevo, D. Bartres Faz, F. Nobili, D. OrlandiL. Parnetti, L. Farotti, C. Costa, P. Payoux, P. M. Rossini, C. Marra, P. Schonknecht, A. Soricelli, G. Noce, M. Salvatore, M. Tsolaki, P. J. Visser, J. C. Richardson, J. Wiltfang, R. Bordet, O. Blin, G. B. Frisoniand

Research output: Contribution to journalArticle

Abstract

Auditory "oddball" event-related potentials (aoERPs), resting state functional magnetic resonance imaging (rsfMRI) connectivity, and electroencephalographic (rsEEG) rhythms were tested as longitudinal functional biomarkers of prodromal Alzheimer's disease (AD). Data were collected at baseline and four follow-ups at 6, 12, 18, and 24 months in amnesic mild cognitive impairment (aMCI) patients classified in two groups: "positive" (i.e., "prodromal AD"; n = 81) or "negative" (n = 63) based on a diagnostic marker of AD derived from cerebrospinal samples (Abeta42/P-tau ratio). A linear mixed model design was used to test functional biomarkers for Group, Time, and GroupxTime effects adjusted by nuisance covariates (only data until conversion to dementia was used). Functional biomarkers that showed significant Group effects ("positive" versus "negative", p <0.05) regardless of Time were 1) reduced rsfMRI connectivity in both the default mode network (DMN) and the posterior cingulate cortex (PCC), both also giving significant Time effects (connectivity decay regardless of Group); 2) increased rsEEG source activity at delta (
Original languageEnglish
JournalJournal of Alzheimer's disease : JAD
DOIs
Publication statusPublished - Oct 29 2018

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Alzheimer Disease
Biomarkers
Magnetic Resonance Imaging
Gyrus Cinguli
Evoked Potentials
Dementia
Linear Models
Cognitive Dysfunction

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Two-Year Longitudinal Monitoring of Amnestic Mild Cognitive Impairment Patients with Prodromal Alzheimer's Disease Using Topographical Biomarkers Derived from Functional Magnetic Resonance Imaging and Electroencephalographic Activity. / Jovicich, J.; Babiloni, C.; Ferrari, C.; Marizzoni, M.; Moretti, D. V.; Percio, C. Del; Lizio, R.; Lopez, S.; Galluzzi, S.; Albani, D.; Cavaliere, L.; Minati, L.; Didic, M.; Fiedler, U.; Forloni, G.; Hensch, T.; Molinuevo, J. L.; Faz, D. Bartres; Nobili, F.; Orlandi, D.; Parnetti, L.; Farotti, L.; Costa, C.; Payoux, P.; Rossini, P. M.; Marra, C.; Schonknecht, P.; Soricelli, A.; Noce, G.; Salvatore, M.; Tsolaki, M.; Visser, P. J.; Richardson, J. C.; Wiltfang, J.; Bordet, R.; Blin, O.; Frisoniand, G. B.

In: Journal of Alzheimer's disease : JAD, 29.10.2018.

Research output: Contribution to journalArticle

Jovicich, J, Babiloni, C, Ferrari, C, Marizzoni, M, Moretti, DV, Percio, CD, Lizio, R, Lopez, S, Galluzzi, S, Albani, D, Cavaliere, L, Minati, L, Didic, M, Fiedler, U, Forloni, G, Hensch, T, Molinuevo, JL, Faz, DB, Nobili, F, Orlandi, D, Parnetti, L, Farotti, L, Costa, C, Payoux, P, Rossini, PM, Marra, C, Schonknecht, P, Soricelli, A, Noce, G, Salvatore, M, Tsolaki, M, Visser, PJ, Richardson, JC, Wiltfang, J, Bordet, R, Blin, O & Frisoniand, GB 2018, 'Two-Year Longitudinal Monitoring of Amnestic Mild Cognitive Impairment Patients with Prodromal Alzheimer's Disease Using Topographical Biomarkers Derived from Functional Magnetic Resonance Imaging and Electroencephalographic Activity', Journal of Alzheimer's disease : JAD. https://doi.org/10.3233/JAD-180158 [doi]
Jovicich, J. ; Babiloni, C. ; Ferrari, C. ; Marizzoni, M. ; Moretti, D. V. ; Percio, C. Del ; Lizio, R. ; Lopez, S. ; Galluzzi, S. ; Albani, D. ; Cavaliere, L. ; Minati, L. ; Didic, M. ; Fiedler, U. ; Forloni, G. ; Hensch, T. ; Molinuevo, J. L. ; Faz, D. Bartres ; Nobili, F. ; Orlandi, D. ; Parnetti, L. ; Farotti, L. ; Costa, C. ; Payoux, P. ; Rossini, P. M. ; Marra, C. ; Schonknecht, P. ; Soricelli, A. ; Noce, G. ; Salvatore, M. ; Tsolaki, M. ; Visser, P. J. ; Richardson, J. C. ; Wiltfang, J. ; Bordet, R. ; Blin, O. ; Frisoniand, G. B. / Two-Year Longitudinal Monitoring of Amnestic Mild Cognitive Impairment Patients with Prodromal Alzheimer's Disease Using Topographical Biomarkers Derived from Functional Magnetic Resonance Imaging and Electroencephalographic Activity. In: Journal of Alzheimer's disease : JAD. 2018.
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T1 - Two-Year Longitudinal Monitoring of Amnestic Mild Cognitive Impairment Patients with Prodromal Alzheimer's Disease Using Topographical Biomarkers Derived from Functional Magnetic Resonance Imaging and Electroencephalographic Activity

AU - Jovicich, J.

AU - Babiloni, C.

AU - Ferrari, C.

AU - Marizzoni, M.

AU - Moretti, D. V.

AU - Percio, C. Del

AU - Lizio, R.

AU - Lopez, S.

AU - Galluzzi, S.

AU - Albani, D.

AU - Cavaliere, L.

AU - Minati, L.

AU - Didic, M.

AU - Fiedler, U.

AU - Forloni, G.

AU - Hensch, T.

AU - Molinuevo, J. L.

AU - Faz, D. Bartres

AU - Nobili, F.

AU - Orlandi, D.

AU - Parnetti, L.

AU - Farotti, L.

AU - Costa, C.

AU - Payoux, P.

AU - Rossini, P. M.

AU - Marra, C.

AU - Schonknecht, P.

AU - Soricelli, A.

AU - Noce, G.

AU - Salvatore, M.

AU - Tsolaki, M.

AU - Visser, P. J.

AU - Richardson, J. C.

AU - Wiltfang, J.

AU - Bordet, R.

AU - Blin, O.

AU - Frisoniand, G. B.

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PY - 2018/10/29

Y1 - 2018/10/29

N2 - Auditory "oddball" event-related potentials (aoERPs), resting state functional magnetic resonance imaging (rsfMRI) connectivity, and electroencephalographic (rsEEG) rhythms were tested as longitudinal functional biomarkers of prodromal Alzheimer's disease (AD). Data were collected at baseline and four follow-ups at 6, 12, 18, and 24 months in amnesic mild cognitive impairment (aMCI) patients classified in two groups: "positive" (i.e., "prodromal AD"; n = 81) or "negative" (n = 63) based on a diagnostic marker of AD derived from cerebrospinal samples (Abeta42/P-tau ratio). A linear mixed model design was used to test functional biomarkers for Group, Time, and GroupxTime effects adjusted by nuisance covariates (only data until conversion to dementia was used). Functional biomarkers that showed significant Group effects ("positive" versus "negative", p <0.05) regardless of Time were 1) reduced rsfMRI connectivity in both the default mode network (DMN) and the posterior cingulate cortex (PCC), both also giving significant Time effects (connectivity decay regardless of Group); 2) increased rsEEG source activity at delta (

AB - Auditory "oddball" event-related potentials (aoERPs), resting state functional magnetic resonance imaging (rsfMRI) connectivity, and electroencephalographic (rsEEG) rhythms were tested as longitudinal functional biomarkers of prodromal Alzheimer's disease (AD). Data were collected at baseline and four follow-ups at 6, 12, 18, and 24 months in amnesic mild cognitive impairment (aMCI) patients classified in two groups: "positive" (i.e., "prodromal AD"; n = 81) or "negative" (n = 63) based on a diagnostic marker of AD derived from cerebrospinal samples (Abeta42/P-tau ratio). A linear mixed model design was used to test functional biomarkers for Group, Time, and GroupxTime effects adjusted by nuisance covariates (only data until conversion to dementia was used). Functional biomarkers that showed significant Group effects ("positive" versus "negative", p <0.05) regardless of Time were 1) reduced rsfMRI connectivity in both the default mode network (DMN) and the posterior cingulate cortex (PCC), both also giving significant Time effects (connectivity decay regardless of Group); 2) increased rsEEG source activity at delta (

U2 - 10.3233/JAD-180158 [doi]

DO - 10.3233/JAD-180158 [doi]

M3 - Article

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

ER -