TY - JOUR
T1 - Type 1 autoimmune hepatitis and adipokines
T2 - New markers for activity and disease progression?
AU - Durazzo, Marilena
AU - Niro, Grazia
AU - Premoli, Alberto
AU - Morello, Enrico
AU - Rizzotto, Erik Rosa
AU - Gambino, Roberto
AU - Bo, Simona
AU - Musso, Giovanni
AU - Cassader, Maurizio
AU - Pagano, Gianfranco
AU - Floreani, Annarosa
PY - 2009
Y1 - 2009
N2 - Purpose: Cytokines may play an important role as inflammatory factors in liver diseases. There is some evidence suggesting a link between adiponectin-biliary function and liver disease. The aim of this study was to clarify the behavior of adipokines in autoimmune hepatitis type 1. Methods: We assessed the circulating levels of adiponectin, tumor necrosis factor-α, resistin and leptin in 42 patients with autoimmune hepatitis, comparing them with 42 healthy subjects who were matched for age and sex and with 31 patients with nonalcoholic steatohepatitis (NASH), evaluating the associations with markers of cytolysis, cholestasis, and histological severity. Results: Adiponectin and TNF-α values were higher in patients compared to controls. The patients showed significantly higher Homeostasis Model Assessment values, suggesting an increased insulin resistance and serum levels of adiponectin positively correlated with γ-glutamyltranspeptidase and alkaline phosphatase values after a simple regression analysis. Serum levels of resistin positively correlated with elevated aminotransferases and bilirubin values, and serum levels of TNF-α positively correlated with elevated alanine-aminotransferase and resistin values. The concentration of adiponectin increased significantly with staging of the disease. Patients with NASH showed lower levels of adiponectin and higher levels of resistin than AIH patients and controls. Conclusions: Patients with AIH showed significantly higher adiponectin concentrations than controls despite their higher HOMA-IR values. The significant correlation between adiponectin levels and serological features of cholestasis suggested an association with biliary function. Our results indicate that adiponectin may be a possible marker for disease progression in AIH.
AB - Purpose: Cytokines may play an important role as inflammatory factors in liver diseases. There is some evidence suggesting a link between adiponectin-biliary function and liver disease. The aim of this study was to clarify the behavior of adipokines in autoimmune hepatitis type 1. Methods: We assessed the circulating levels of adiponectin, tumor necrosis factor-α, resistin and leptin in 42 patients with autoimmune hepatitis, comparing them with 42 healthy subjects who were matched for age and sex and with 31 patients with nonalcoholic steatohepatitis (NASH), evaluating the associations with markers of cytolysis, cholestasis, and histological severity. Results: Adiponectin and TNF-α values were higher in patients compared to controls. The patients showed significantly higher Homeostasis Model Assessment values, suggesting an increased insulin resistance and serum levels of adiponectin positively correlated with γ-glutamyltranspeptidase and alkaline phosphatase values after a simple regression analysis. Serum levels of resistin positively correlated with elevated aminotransferases and bilirubin values, and serum levels of TNF-α positively correlated with elevated alanine-aminotransferase and resistin values. The concentration of adiponectin increased significantly with staging of the disease. Patients with NASH showed lower levels of adiponectin and higher levels of resistin than AIH patients and controls. Conclusions: Patients with AIH showed significantly higher adiponectin concentrations than controls despite their higher HOMA-IR values. The significant correlation between adiponectin levels and serological features of cholestasis suggested an association with biliary function. Our results indicate that adiponectin may be a possible marker for disease progression in AIH.
KW - Adiponectin
KW - Autoimmune hepatitis
KW - Leptin
KW - Resistin
KW - TNF-α
UR - http://www.scopus.com/inward/record.url?scp=67349127257&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349127257&partnerID=8YFLogxK
U2 - 10.1007/s00535-009-0023-0
DO - 10.1007/s00535-009-0023-0
M3 - Article
C2 - 19301087
AN - SCOPUS:67349127257
VL - 44
SP - 476
EP - 482
JO - Journal of Gastroenterology
JF - Journal of Gastroenterology
SN - 0944-1174
IS - 5
ER -