Type 1 immune response in progressive multiple sclerosis

Giovanni Frisullo, Domenico Plantone, Alessandro Marti, Raffaele Iorio, Valentina Damato, Viviana Nociti, Agata Katia Patanella, Assunta Bianco, Anna Paola Batocchi

Research output: Contribution to journalArticle


The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4 +T-bet + and CD8 +T-bet + T cells in SPMS and PPMS than in remitting-relapsing MS patients and controls. Moreover, in SPMS, we observed a positive correlation between the percentages of circulating CD4 +T-bet + or CD8 +T-bet + T cells and disease severity. The increased percentages of Th1 and Tc1 cells suggest that MS progressive forms, unlike RRMS, are characterized by a permanent peripheral type-1 immune activation.

Original languageEnglish
Pages (from-to)112-116
Number of pages5
JournalJournal of Neuroimmunology
Issue number1-2
Publication statusPublished - Aug 15 2012


  • Multiple sclerosis
  • PPMS
  • SPMS
  • T-bet
  • Transcription factor

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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  • Cite this

    Frisullo, G., Plantone, D., Marti, A., Iorio, R., Damato, V., Nociti, V., Patanella, A. K., Bianco, A., & Batocchi, A. P. (2012). Type 1 immune response in progressive multiple sclerosis. Journal of Neuroimmunology, 249(1-2), 112-116. https://doi.org/10.1016/j.jneuroim.2012.04.019