Type 1/type 2 cytokine modulation of T-cell programed cell death as a model for human immunodeficiency virus pathogenesis

Mario Clerici, Apurva Sarin, Robert L. Coffman, Thomas A. Wynn, Stephen P. Blatt, Craig W. Hendrix, Stanley F. Wolf, Gene M. Shearer, Pierre A. Henkart

Research output: Contribution to journalArticle

Abstract

In vitro T-cell receptor-induced programed cell death in both activated T cells from human immunodeficiency virus-seronegative (HIV-) donors and resting T cells from HIV+ donors was substantially influenced by cytokines. Addition of exogenous recombinant 'type 1' lymphokines interferon γ and interleukin 2 (IL-2), as well as the macrophage-produced IL-12, which favor cell-mediated T-cell responses, blocks both systems of T-lymphocyte programed cell death. In contrast, the 'type 2' lymphokines IL-4 and IL-10, which favor antibody responses, either had no effect or enhanced these systems of in vitro T-cell programed cell death. A role for endogenously produced cytokines was suggested by the inhibition of T-cell receptor-mediated death by antibodies against IL-4 and IL-10 and its enhancement by anti-IL-12 in cultures containing monocytes. These results demonstrate that the functional properties of type 1 and type 2 cytokine classes may be further extended to include their effects on T-cell programed cell death and their possible role in the pathogenesis of HIV infection.

Original languageEnglish
Pages (from-to)11811-11815
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume91
Issue number25
DOIs
Publication statusPublished - Dec 6 1994

ASJC Scopus subject areas

  • Genetics
  • General

Fingerprint Dive into the research topics of 'Type 1/type 2 cytokine modulation of T-cell programed cell death as a model for human immunodeficiency virus pathogenesis'. Together they form a unique fingerprint.

  • Cite this