Type 2 cytotoxic T lymphocytes modulate the activity of dendritic cells toward type 2 immune responses

Giandomenica Iezzi, Andrea Boni, Elena Degl'Innocenti, Matteo Grioni, Maria T S Bertilaccio, Matteo Bellone

Research output: Contribution to journalArticle

Abstract

Activated CD8+ T cells can differentiate into type 1 (Tc1) cells, producing mainly IFN-γ, and type 2 (Tc2) cells, producing mostly IL-4, IL-5, and IL-10. Tc1 cells are potent CTL involved in the defense against intracellular pathogens and cancer cells. The role of Tc2 cells in the immune response is largely unknown, although their presence in chronic infections, cancer, and autoimmune diseases is associated with disease severity and progression. Here, we show that mouse Tc2 cells modify, through a cell-to-cell contact mechanism, the function of bone marrow-derived dendritic cells (DC). Indeed, Tc2-conditioned DC displayed a reduced expression of MHC class II and costimulatory molecules, produced IL-10 instead of IL-12, and favored the differentiation of both naive CD4+ and CD8+ T cells toward type 2 cells in the absence of added polarizing cytokines. The novel function for Tc2 cells suggests a type 2 loop in which Tc2 cells modify DC function and favor differentiation of naive T cells to type 2 cells. The type 2 loop may at least in part explain the unexpected high frequency of type 2 cells during a chronic exposure to the Ag.

Original languageEnglish
Pages (from-to)2131-2137
Number of pages7
JournalJournal of Immunology
Volume177
Issue number4
Publication statusPublished - Aug 15 2006

ASJC Scopus subject areas

  • Immunology

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    Iezzi, G., Boni, A., Degl'Innocenti, E., Grioni, M., Bertilaccio, M. T. S., & Bellone, M. (2006). Type 2 cytotoxic T lymphocytes modulate the activity of dendritic cells toward type 2 immune responses. Journal of Immunology, 177(4), 2131-2137.