Type 2 diabetes: How much of an autoimmune disease?

Paola De Candia, Francesco Prattichizzo, Silvia Garavelli, Veronica De Rosa, Mario Galgani, Francesca Di Rella, Maria Immacolata Spagnuolo, Alessandra Colamatteo, Clorinda Fusco, Teresa Micillo, Sara Bruzzaniti, Antonio Ceriello, Annibale A. Puca, Giuseppe Matarese

Research output: Contribution to journalReview article

Abstract

Type 2 diabetes (T2D) is characterized by a progressive status of chronic, low-grade inflammation (LGI) that accompanies the whole trajectory of the disease, from its inception to complication development. Accumulating evidence is disclosing a long list of possible “triggers” of inflammatory responses, many of which are promoted by unhealthy lifestyle choices and advanced age. Diabetic patients show an altered number and function of immune cells, of both innate and acquired immunity. Reactive autoantibodies against islet antigens can be detected in a subpopulation of patients, while emerging data are also suggesting an altered function of specific T lymphocyte populations, including T regulatory (Treg) cells. These observations led to the hypothesis that part of the inflammatory response mounting in T2D is attributable to an autoimmune phenomenon. Here, we review recent data supporting this framework, with a specific focus on both tissue resident and circulating Treg populations. We also propose that selective interception (or expansion) of T cell subsets could be an alternative avenue to dampen inappropriate inflammatory responses without compromising immune responses.

Original languageEnglish
Article number451
JournalFrontiers in Endocrinology
Volume10
Issue numberJULY
DOIs
Publication statusPublished - Jan 1 2019

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Type 2 Diabetes Mellitus
Autoimmune Diseases
T-Lymphocyte Subsets
Adaptive Immunity
Regulatory T-Lymphocytes
Innate Immunity
Autoantibodies
Population
Life Style
Inflammation
T-Lymphocytes
Antigens

Keywords

  • Autoimmunity
  • Diabetes
  • Immunometabolism
  • Inflammation
  • T cells

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Type 2 diabetes : How much of an autoimmune disease? / De Candia, Paola; Prattichizzo, Francesco; Garavelli, Silvia; De Rosa, Veronica; Galgani, Mario; Rella, Francesca Di; Spagnuolo, Maria Immacolata; Colamatteo, Alessandra; Fusco, Clorinda; Micillo, Teresa; Bruzzaniti, Sara; Ceriello, Antonio; Puca, Annibale A.; Matarese, Giuseppe.

In: Frontiers in Endocrinology, Vol. 10, No. JULY, 451, 01.01.2019.

Research output: Contribution to journalReview article

De Candia, P, Prattichizzo, F, Garavelli, S, De Rosa, V, Galgani, M, Rella, FD, Spagnuolo, MI, Colamatteo, A, Fusco, C, Micillo, T, Bruzzaniti, S, Ceriello, A, Puca, AA & Matarese, G 2019, 'Type 2 diabetes: How much of an autoimmune disease?', Frontiers in Endocrinology, vol. 10, no. JULY, 451. https://doi.org/10.3389/fendo.2019.00451
De Candia, Paola ; Prattichizzo, Francesco ; Garavelli, Silvia ; De Rosa, Veronica ; Galgani, Mario ; Rella, Francesca Di ; Spagnuolo, Maria Immacolata ; Colamatteo, Alessandra ; Fusco, Clorinda ; Micillo, Teresa ; Bruzzaniti, Sara ; Ceriello, Antonio ; Puca, Annibale A. ; Matarese, Giuseppe. / Type 2 diabetes : How much of an autoimmune disease?. In: Frontiers in Endocrinology. 2019 ; Vol. 10, No. JULY.
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