Type 2 diabetes mellitus predicts worse outcomes in patients with high-grade T1 bladder cancer receiving bacillus Calmette-Guérin after transurethral resection of the bladder tumor

Matteo Ferro; Martha Orsolya Katalin; Carlo Buonerba; Raluca Marian; Francesco Cantiello; Gennaro Musi; Savino Di Stasi; Rodolfo Hurle; Giorgio Guazzoni; Gian Maria Busetto; Francesco Del Giudice; Sisto Perdonà; Paola Del Prete; Vincenzo Mirone; Marco Borghesi; Angelo Porreca; Walter Artibani; Pierluigi Bove; Estevao Lima; Riccardo Autorino; Nicolae Crisan; Abdal Rahman Abu Farhan; Michele Battaglia; Pasquale Ditonno; Vincenzo Serretta; Giorgio Ivan Russo; Daniela Terracciano; Giuseppe di Lorenzo; Rocco Damiano; Guru Sonpavde; Mihai Dorin Vartolomei; Ottavio de Cobelli; Giuseppe Lucarelli

doi:10.1016/j.urolonc.2020.02.016

Type 2 diabetes mellitus predicts worse outcomes in patients with high-grade T1 bladder cancer receiving bacillus Calmette-Guérin after transurethral resection of the bladder tumor

Matteo Ferro, Martha Orsolya Katalin, Carlo Buonerba, Raluca Marian, Francesco Cantiello, Gennaro Musi, Savino Di Stasi, Rodolfo Hurle, Giorgio Guazzoni, Gian Maria Busetto, Francesco Del Giudice, Sisto Perdonà, Paola Del Prete, Vincenzo Mirone, Marco Borghesi, Angelo Porreca, Walter Artibani, Pierluigi Bove, Estevao Lima, Riccardo AutorinoNicolae Crisan, Abdal Rahman Abu Farhan, Michele Battaglia, Pasquale Ditonno, Vincenzo Serretta, Giorgio Ivan Russo, Daniela Terracciano, Giuseppe di Lorenzo, Rocco Damiano, Guru Sonpavde, Mihai Dorin Vartolomei, Ottavio de Cobelli, Giuseppe Lucarelli

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVES: The aim of this multicenter study was to investigate the prognostic role of type 2 diabetes mellitus (T2DM) comorbidity in a large multi-institutional cohort of patients with primary T1HG/G3 non-muscle-invasive bladder cancer (NMIBC) treated with transurethral resection of the bladder (TURB).

MATERIALS AND METHODS: A total of 1,172 patients with primary T1 HG/G3 who had NMIBC on re-TURB and who received adjuvant intravesical bacillus Calmette-Guérin therapy with maintenance were included. Endpoints were recurrence-free survival and progression-free survival.

RESULTS: A total of 231 (19.7%) of patients had T2DM prior to TURB. Five-year recurrence-free survival estimates were 12.5% in patients with T2DM compared to 36% in patients without T2DM, P < 0.0001. Five-year PFS estimates were 60.5% in patients with T2DM compared to 70.2% in patients without T2DM, P = 0.003. T2DM was independently associated with disease recurrence (hazard ratio = 1.41; 95% confidence interval = 1.20-1.66, P < 0.001) and progression (hazard ratio = 1.27; 95% confidence interval = 0.99-1.63, P < 0.001), after adjusting for other known predictive factors such as tumor size, multifocality, T1G3 on re-TURB, body mass index, lymphovascular invasion, and neutrophil-to-lymphocytes ratio.

CONCLUSIONS: Given the potential implications for management, prospective validation of this finding along with translational studies designed to investigate the underlying biology of such an association are warranted.

Original language	English
Pages (from-to)	459-464
Number of pages	6
Journal	Urol. Oncol. Semin. Orig. Invest.
Volume	38
Issue number	5
DOIs	https://doi.org/10.1016/j.urolonc.2020.02.016
Publication status	Published - May 2020

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Ferro, M., Katalin, M. O., Buonerba, C., Marian, R., Cantiello, F., Musi, G., Di Stasi, S., Hurle, R., Guazzoni, G., Busetto, G. M., Del Giudice, F., Perdonà, S., Del Prete, P., Mirone, V., Borghesi, M., Porreca, A., Artibani, W., Bove, P., Lima, E., ... Lucarelli, G. (2020). Type 2 diabetes mellitus predicts worse outcomes in patients with high-grade T1 bladder cancer receiving bacillus Calmette-Guérin after transurethral resection of the bladder tumor. Urol. Oncol. Semin. Orig. Invest., 38(5), 459-464. https://doi.org/10.1016/j.urolonc.2020.02.016

Type 2 diabetes mellitus predicts worse outcomes in patients with high-grade T1 bladder cancer receiving bacillus Calmette-Guérin after transurethral resection of the bladder tumor. / Ferro, Matteo; Katalin, Martha Orsolya; Buonerba, Carlo; Marian, Raluca; Cantiello, Francesco; Musi, Gennaro; Di Stasi, Savino; Hurle, Rodolfo; Guazzoni, Giorgio; Busetto, Gian Maria; Del Giudice, Francesco; Perdonà, Sisto ; Del Prete, Paola; Mirone, Vincenzo; Borghesi, Marco; Porreca, Angelo; Artibani, Walter; Bove, Pierluigi; Lima, Estevao; Autorino, Riccardo; Crisan, Nicolae; Abu Farhan, Abdal Rahman; Battaglia, Michele; Ditonno, Pasquale; Serretta, Vincenzo; Russo, Giorgio Ivan; Terracciano, Daniela; di Lorenzo, Giuseppe; Damiano, Rocco; Sonpavde, Guru; Vartolomei, Mihai Dorin; de Cobelli, Ottavio; Lucarelli, Giuseppe.

In: Urol. Oncol. Semin. Orig. Invest., Vol. 38, No. 5, 05.2020, p. 459-464.

Research output: Contribution to journal › Article › peer-review

Ferro, M, Katalin, MO, Buonerba, C, Marian, R, Cantiello, F, Musi, G, Di Stasi, S, Hurle, R, Guazzoni, G, Busetto, GM, Del Giudice, F, Perdonà, S , Del Prete, P, Mirone, V, Borghesi, M, Porreca, A, Artibani, W, Bove, P, Lima, E, Autorino, R, Crisan, N, Abu Farhan, AR, Battaglia, M, Ditonno, P, Serretta, V, Russo, GI, Terracciano, D, di Lorenzo, G, Damiano, R, Sonpavde, G, Vartolomei, MD, de Cobelli, O & Lucarelli, G 2020, 'Type 2 diabetes mellitus predicts worse outcomes in patients with high-grade T1 bladder cancer receiving bacillus Calmette-Guérin after transurethral resection of the bladder tumor', Urol. Oncol. Semin. Orig. Invest., vol. 38, no. 5, pp. 459-464. https://doi.org/10.1016/j.urolonc.2020.02.016

Ferro, Matteo ; Katalin, Martha Orsolya ; Buonerba, Carlo ; Marian, Raluca ; Cantiello, Francesco ; Musi, Gennaro ; Di Stasi, Savino ; Hurle, Rodolfo ; Guazzoni, Giorgio ; Busetto, Gian Maria ; Del Giudice, Francesco ; Perdonà, Sisto ; Del Prete, Paola ; Mirone, Vincenzo ; Borghesi, Marco ; Porreca, Angelo ; Artibani, Walter ; Bove, Pierluigi ; Lima, Estevao ; Autorino, Riccardo ; Crisan, Nicolae ; Abu Farhan, Abdal Rahman ; Battaglia, Michele ; Ditonno, Pasquale ; Serretta, Vincenzo ; Russo, Giorgio Ivan ; Terracciano, Daniela ; di Lorenzo, Giuseppe ; Damiano, Rocco ; Sonpavde, Guru ; Vartolomei, Mihai Dorin ; de Cobelli, Ottavio ; Lucarelli, Giuseppe. / Type 2 diabetes mellitus predicts worse outcomes in patients with high-grade T1 bladder cancer receiving bacillus Calmette-Guérin after transurethral resection of the bladder tumor. In: Urol. Oncol. Semin. Orig. Invest. 2020 ; Vol. 38, No. 5. pp. 459-464.

@article{6fbbe3e205734488b3dc7e6abad81640,

title = "Type 2 diabetes mellitus predicts worse outcomes in patients with high-grade T1 bladder cancer receiving bacillus Calmette-Gu{\'e}rin after transurethral resection of the bladder tumor",

abstract = "OBJECTIVES: The aim of this multicenter study was to investigate the prognostic role of type 2 diabetes mellitus (T2DM) comorbidity in a large multi-institutional cohort of patients with primary T1HG/G3 non-muscle-invasive bladder cancer (NMIBC) treated with transurethral resection of the bladder (TURB).MATERIALS AND METHODS: A total of 1,172 patients with primary T1 HG/G3 who had NMIBC on re-TURB and who received adjuvant intravesical bacillus Calmette-Gu{\'e}rin therapy with maintenance were included. Endpoints were recurrence-free survival and progression-free survival.RESULTS: A total of 231 (19.7%) of patients had T2DM prior to TURB. Five-year recurrence-free survival estimates were 12.5% in patients with T2DM compared to 36% in patients without T2DM, P < 0.0001. Five-year PFS estimates were 60.5% in patients with T2DM compared to 70.2% in patients without T2DM, P = 0.003. T2DM was independently associated with disease recurrence (hazard ratio = 1.41; 95% confidence interval = 1.20-1.66, P < 0.001) and progression (hazard ratio = 1.27; 95% confidence interval = 0.99-1.63, P < 0.001), after adjusting for other known predictive factors such as tumor size, multifocality, T1G3 on re-TURB, body mass index, lymphovascular invasion, and neutrophil-to-lymphocytes ratio.CONCLUSIONS: Given the potential implications for management, prospective validation of this finding along with translational studies designed to investigate the underlying biology of such an association are warranted.",

author = "Matteo Ferro and Katalin, {Martha Orsolya} and Carlo Buonerba and Raluca Marian and Francesco Cantiello and Gennaro Musi and {Di Stasi}, Savino and Rodolfo Hurle and Giorgio Guazzoni and Busetto, {Gian Maria} and {Del Giudice}, Francesco and Sisto Perdon{\`a} and {Del Prete}, Paola and Vincenzo Mirone and Marco Borghesi and Angelo Porreca and Walter Artibani and Pierluigi Bove and Estevao Lima and Riccardo Autorino and Nicolae Crisan and {Abu Farhan}, {Abdal Rahman} and Michele Battaglia and Pasquale Ditonno and Vincenzo Serretta and Russo, {Giorgio Ivan} and Daniela Terracciano and {di Lorenzo}, Giuseppe and Rocco Damiano and Guru Sonpavde and Vartolomei, {Mihai Dorin} and {de Cobelli}, Ottavio and Giuseppe Lucarelli",

year = "2020",

month = may,

doi = "10.1016/j.urolonc.2020.02.016",

language = "English",

volume = "38",

pages = "459--464",

journal = "Urol. Oncol. Semin. Orig. Invest.",

issn = "1078-1439",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Type 2 diabetes mellitus predicts worse outcomes in patients with high-grade T1 bladder cancer receiving bacillus Calmette-Guérin after transurethral resection of the bladder tumor

AU - Ferro, Matteo

AU - Katalin, Martha Orsolya

AU - Buonerba, Carlo

AU - Marian, Raluca

AU - Cantiello, Francesco

AU - Musi, Gennaro

AU - Di Stasi, Savino

AU - Hurle, Rodolfo

AU - Guazzoni, Giorgio

AU - Busetto, Gian Maria

AU - Del Giudice, Francesco

AU - Perdonà, Sisto

AU - Del Prete, Paola

AU - Mirone, Vincenzo

AU - Borghesi, Marco

AU - Porreca, Angelo

AU - Artibani, Walter

AU - Bove, Pierluigi

AU - Lima, Estevao

AU - Autorino, Riccardo

AU - Crisan, Nicolae

AU - Abu Farhan, Abdal Rahman

AU - Battaglia, Michele

AU - Ditonno, Pasquale

AU - Serretta, Vincenzo

AU - Russo, Giorgio Ivan

AU - Terracciano, Daniela

AU - di Lorenzo, Giuseppe

AU - Damiano, Rocco

AU - Sonpavde, Guru

AU - Vartolomei, Mihai Dorin

AU - de Cobelli, Ottavio

AU - Lucarelli, Giuseppe

PY - 2020/5

Y1 - 2020/5

N2 - OBJECTIVES: The aim of this multicenter study was to investigate the prognostic role of type 2 diabetes mellitus (T2DM) comorbidity in a large multi-institutional cohort of patients with primary T1HG/G3 non-muscle-invasive bladder cancer (NMIBC) treated with transurethral resection of the bladder (TURB).MATERIALS AND METHODS: A total of 1,172 patients with primary T1 HG/G3 who had NMIBC on re-TURB and who received adjuvant intravesical bacillus Calmette-Guérin therapy with maintenance were included. Endpoints were recurrence-free survival and progression-free survival.RESULTS: A total of 231 (19.7%) of patients had T2DM prior to TURB. Five-year recurrence-free survival estimates were 12.5% in patients with T2DM compared to 36% in patients without T2DM, P < 0.0001. Five-year PFS estimates were 60.5% in patients with T2DM compared to 70.2% in patients without T2DM, P = 0.003. T2DM was independently associated with disease recurrence (hazard ratio = 1.41; 95% confidence interval = 1.20-1.66, P < 0.001) and progression (hazard ratio = 1.27; 95% confidence interval = 0.99-1.63, P < 0.001), after adjusting for other known predictive factors such as tumor size, multifocality, T1G3 on re-TURB, body mass index, lymphovascular invasion, and neutrophil-to-lymphocytes ratio.CONCLUSIONS: Given the potential implications for management, prospective validation of this finding along with translational studies designed to investigate the underlying biology of such an association are warranted.

AB - OBJECTIVES: The aim of this multicenter study was to investigate the prognostic role of type 2 diabetes mellitus (T2DM) comorbidity in a large multi-institutional cohort of patients with primary T1HG/G3 non-muscle-invasive bladder cancer (NMIBC) treated with transurethral resection of the bladder (TURB).MATERIALS AND METHODS: A total of 1,172 patients with primary T1 HG/G3 who had NMIBC on re-TURB and who received adjuvant intravesical bacillus Calmette-Guérin therapy with maintenance were included. Endpoints were recurrence-free survival and progression-free survival.RESULTS: A total of 231 (19.7%) of patients had T2DM prior to TURB. Five-year recurrence-free survival estimates were 12.5% in patients with T2DM compared to 36% in patients without T2DM, P < 0.0001. Five-year PFS estimates were 60.5% in patients with T2DM compared to 70.2% in patients without T2DM, P = 0.003. T2DM was independently associated with disease recurrence (hazard ratio = 1.41; 95% confidence interval = 1.20-1.66, P < 0.001) and progression (hazard ratio = 1.27; 95% confidence interval = 0.99-1.63, P < 0.001), after adjusting for other known predictive factors such as tumor size, multifocality, T1G3 on re-TURB, body mass index, lymphovascular invasion, and neutrophil-to-lymphocytes ratio.CONCLUSIONS: Given the potential implications for management, prospective validation of this finding along with translational studies designed to investigate the underlying biology of such an association are warranted.

U2 - 10.1016/j.urolonc.2020.02.016

DO - 10.1016/j.urolonc.2020.02.016

M3 - Article

C2 - 32173242

VL - 38

SP - 459

EP - 464

JO - Urol. Oncol. Semin. Orig. Invest.

JF - Urol. Oncol. Semin. Orig. Invest.

SN - 1078-1439

IS - 5

ER -

Type 2 diabetes mellitus predicts worse outcomes in patients with high-grade T1 bladder cancer receiving bacillus Calmette-Guérin after transurethral resection of the bladder tumor

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