Type 2 diabetes mellitus treatment habits in a specialized care setting: The START-DIAB study

Sandro Gentile, Antonio Ceriello, Giuseppe Pipicelli, Felice Strollo, START DIAB Study Group

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Early optimized lifestyle and medication treatment can reduce the burden of type 2 diabetes mellitus (T2DM). Although Diabetologists take care of most Italian people withT2DMand are the only allowed to prescribe innovative drugs, still half T2DM patients are poorly controlled. AIMS: To verify specialists’ propensity to reach individualized glycemic goals by treating to target newly referred people with T2DM having HbA1c levels >7% (>53 mmol/mol). MATERIALS AND METHODS: 2536 poorly controlled, orally treated T2DM from all over Italy were evaluated and followed up for 6 months for appropriate nutritional and pharmacologic treatment in a specialized setting and diabetologists filled in a questionnaire on supposed reasons behind patients’ poor metabolic control and on their own therapeutic choices. RESULTS: At the first visit only 71.8% people underwent slight treatment adaptations (through a slight reduction of secretagogue utilization accompanied, to a lesser extent, by some increase in incretin prescription (from 13.4% to 33.5%; p < 001) and by de novo insulin administration (3.8%). Specialists stated three major reasons for poor control as observed at referral. Two of them, i.e. disease per se (secondary failure) and patients’ attitude (poor adherence), were high-rated, while the other one, addressing clinicians’ responsibility, was only marginally accounted for despite most diabetes specialists still going on with secretagogues all the time. Detailed results are provided within the text.

Original languageEnglish
Pages (from-to)165-179
Number of pages15
JournalMediterranean Journal of Nutrition and Metabolism
Issue number2
Publication statusPublished - Jan 1 2017

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Food Science
  • Nutrition and Dietetics


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