Type A modules: Interacting domains found in several non-fibrillar collagens and in other extracellular matrix proteins

A. Colombatti, P. Bonaldo, R. Doliana

Research output: Contribution to journalArticle

Abstract

A 200-amino acid long motif first recognized in von Willebrand Factor (type A module) has been found in components of the extracellular matrix, hemostasis, cellular adhesion, and immune defense mechanisms. At present the extracellular matrix is the predominant site of expression of type A modules since at least four non-fibrillar collagens and two non-collagenous proteins contain a variable number of modules ranging from one to twelve. The medules conform to a consensus motif made of short conserved subregions separated by stretches of variable length. The proteins that incorporate type A modules participate in numerous biological events such as cell adhesion, migration, homing, pattern formation, and signal transduction after interaction with a large array of ligands.

Original languageEnglish
Pages (from-to)297-306
Number of pages10
JournalMatrix
Volume13
Issue number4
Publication statusPublished - 1993

Keywords

  • Extracellular matrix proteins
  • Non-fibrillar collagens
  • Type A modules

ASJC Scopus subject areas

  • Rheumatology

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