Type I autoimmune hepatitis

Clinical course and outcome in an Italian multicentre study

A. Floreani, G. Niro, E. Rosa Rizzotto, S. Antoniazzi, F. Ferrara, I. Carderi, V. Baldo, A. Premoli, F. Olivero, E. Morello, M. Durazzo

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Background: Many reports of autoimmune hepatitis (AIH) were written in the 'pre-Hepatitis C era' and data on the natural history are still incomplete. Aim: To evaluate the clinical presentation and the natural history of type I AIH. Methods: Seventy-three consecutive patients with a regular follow-up of at least 2 years were prospectively included in the study. The mean follow-up was 91 ± 61 months. Results: Patients with 'acute' onset at presentation were significantly older than patients with 'chronic' onset (P <0.05) and had significantly higher serum levels of transaminase, γ-glutamyltransferase and bilirubin; Prothrombin time was significantly lower in the said group compared with AIH patients with 'chronic' onset. In 4 of 63 (6.3%) female patients, AIH had the onset during pregnancy; in all of them the outcome of pregnancy was favourable. The major events during the follow-up included oesophageal varices (n = 9) and ascites (n = 4), and 60 patients remained in remission while receiving immunosuppression. None of the patients died during the follow-up, but seven patients were transplanted. The cumulative transplant-free probability of survival was 73.5% at 280 months. Conclusions: Elderly patients have more frequently an acute onset at presentation. Survival in AIH is apparently good; with early diagnosis, and improved medical therapy, liver transplantation for AIH will become a rare event in future.

Original languageEnglish
Pages (from-to)1051-1057
Number of pages7
JournalAlimentary Pharmacology and Therapeutics
Volume24
Issue number7
DOIs
Publication statusPublished - Oct 2006

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Autoimmune Hepatitis
Multicenter Studies
Natural History
Survival
Esophageal and Gastric Varices
Prothrombin Time
Pregnancy Outcome
Hepatitis C
Transaminases
Bilirubin
Ascites
Liver Transplantation
Immunosuppression
Early Diagnosis
Transplants
Pregnancy

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Type I autoimmune hepatitis : Clinical course and outcome in an Italian multicentre study. / Floreani, A.; Niro, G.; Rosa Rizzotto, E.; Antoniazzi, S.; Ferrara, F.; Carderi, I.; Baldo, V.; Premoli, A.; Olivero, F.; Morello, E.; Durazzo, M.

In: Alimentary Pharmacology and Therapeutics, Vol. 24, No. 7, 10.2006, p. 1051-1057.

Research output: Contribution to journalArticle

Floreani, A, Niro, G, Rosa Rizzotto, E, Antoniazzi, S, Ferrara, F, Carderi, I, Baldo, V, Premoli, A, Olivero, F, Morello, E & Durazzo, M 2006, 'Type I autoimmune hepatitis: Clinical course and outcome in an Italian multicentre study', Alimentary Pharmacology and Therapeutics, vol. 24, no. 7, pp. 1051-1057. https://doi.org/10.1111/j.1365-2036.2006.03104.x
Floreani, A. ; Niro, G. ; Rosa Rizzotto, E. ; Antoniazzi, S. ; Ferrara, F. ; Carderi, I. ; Baldo, V. ; Premoli, A. ; Olivero, F. ; Morello, E. ; Durazzo, M. / Type I autoimmune hepatitis : Clinical course and outcome in an Italian multicentre study. In: Alimentary Pharmacology and Therapeutics. 2006 ; Vol. 24, No. 7. pp. 1051-1057.
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AU - Carderi, I.

AU - Baldo, V.

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AB - Background: Many reports of autoimmune hepatitis (AIH) were written in the 'pre-Hepatitis C era' and data on the natural history are still incomplete. Aim: To evaluate the clinical presentation and the natural history of type I AIH. Methods: Seventy-three consecutive patients with a regular follow-up of at least 2 years were prospectively included in the study. The mean follow-up was 91 ± 61 months. Results: Patients with 'acute' onset at presentation were significantly older than patients with 'chronic' onset (P <0.05) and had significantly higher serum levels of transaminase, γ-glutamyltransferase and bilirubin; Prothrombin time was significantly lower in the said group compared with AIH patients with 'chronic' onset. In 4 of 63 (6.3%) female patients, AIH had the onset during pregnancy; in all of them the outcome of pregnancy was favourable. The major events during the follow-up included oesophageal varices (n = 9) and ascites (n = 4), and 60 patients remained in remission while receiving immunosuppression. None of the patients died during the follow-up, but seven patients were transplanted. The cumulative transplant-free probability of survival was 73.5% at 280 months. Conclusions: Elderly patients have more frequently an acute onset at presentation. Survival in AIH is apparently good; with early diagnosis, and improved medical therapy, liver transplantation for AIH will become a rare event in future.

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