Type i collagen and matrix metalloproteinase 1, 3 and 9 gene polymorphisms in the predisposition to pelvic organ prolapse

Maria Maddalena Ferrari, Gabriela Rossi, Maria Luisa Biondi, Paola Viganò, Chiara Dell'Utri, Michele Meschia

Research output: Contribution to journalArticlepeer-review

Abstract

Aim To evaluate whether the presence of specific polymorphism in the gene promoter of collagen and some matrix metalloproteinases was associated with the risk of developing pelvic organ prolapse. Methods A case-control study was carried on 233 women: 137 were cases with ≥stage II pelvic organ prolapse and 96 were matched controls without pelvic pathologies. Allele and genotype frequencies related to polymorphisms at the Sp1 site of type I collagen and some functional polymorphisms in the promoters of metallo-proteinases-1, -3 and -9 have been compared between groups. It has been shown that these single-insertions/ deletions polymorphisms located in the promoter region of the genes have a functional significance in the regulation of their transcriptional level and local expression. Genotypes were determined by polymerase chain reaction (PCR) amplification and sequence analysis. SPSS 14.0 software was used for data analysis. Probability values of

Original languageEnglish
Pages (from-to)1581-1586
Number of pages6
JournalArchives of Gynecology and Obstetrics
Volume285
Issue number6
DOIs
Publication statusPublished - Jun 2012

Keywords

  • MMP1
  • MMP3
  • MMP9
  • Pelvic organ prolapse
  • Polymorphism
  • Type I collagen

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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