Type I lamellar ichthyosis improved by tazarotene 0.1% gel

G. C. Marulli, E. Campione, M. S. Chimenti, A. Terrinoni, G. Melino, L. Bianchi

Research output: Contribution to journalArticle

Abstract

The efficacy of tazarotene 0.1% gel in a 30-year-old woman with type I lamellar ichthyosis is reported. The drug was applied to 15% of the total body surface area as follows: once daily for 2 weeks, three times a week for further 2 weeks, followed by a once weekly maintenance application. During the first week of treatment there was partial improvement obtained and in the next 14 days further reduction of scaling within the tazarotene-treated areas was observed. After 4 months of maintenance application, there was a marked overall improvement in the treated areas. Side-effects consisted only of mild pruritus, slight burning and irritation. In essence, the therapeutic benefit obtained was comparable with that of systemic retinoids but without the adverse systemic side-effects. As noted in other reports, tazarotene 0.1% gel seems to be a valuable and safe therapeutic option for this severe genodermatosis.

Original languageEnglish
Pages (from-to)391-393
Number of pages3
JournalClinical and Experimental Dermatology
Volume28
Issue number4
DOIs
Publication statusPublished - Jun 2003

ASJC Scopus subject areas

  • Dermatology

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    Marulli, G. C., Campione, E., Chimenti, M. S., Terrinoni, A., Melino, G., & Bianchi, L. (2003). Type I lamellar ichthyosis improved by tazarotene 0.1% gel. Clinical and Experimental Dermatology, 28(4), 391-393. https://doi.org/10.1046/j.1365-2230.2003.01318.x