Type III neuregulin-1 promotes oligodendrocyte myelination

Carla Taveggia, Pratik Thaker, Ashley Petrylak, Gregg L. Caporaso, Arrel Toews, Douglas L. Falls, Steven Einheber, James L. Salzer

Research output: Contribution to journalArticle

Abstract

The axonal signals that regulate oligodendrocyte myelination during development of the central nervous system (CNS) have not been established. In this study, we have examined the regulation of oligodendrocyte myelination by the type III isoform of neuregulin-1 (NRG1), a neuronal signal essential for Schwann cell differentiation and myelination. In contrast to Schwann cells, primary oligodendrocytes differentiate normally when cocultured with dorsal root ganglia (DRG) neurons deficient in type III NRG1. However, they myelinate type III NRG1-deficient neurites poorly in comparison to wild type cultures. Type III NRG1 is not sufficient to drive oligodendrocyte myelination as sympathetic neurons are not myelinated even with lentiviral-mediated expression of NRG1. Mice haploinsufficient for type III NRG1 are hypomyelinated in the brain, as evidenced by reduced amounts of myelin proteins and lipids and thinner myelin sheaths. In contrast, the optic nerve and spinal cord of heterozygotes are myelinated normally. Together, these results implicate type III NRG1 as a significant determinant of the extent of myelination in the brain and demonstrate important regional differences in the control of CNS myelination. They also indicate that oligodendrocyte myelination, but not differentiation, is promoted by axonal NRG1, underscoring important differences in the control of myelination in the CNS and peripheral nervous system (PNS).

Original languageEnglish
Pages (from-to)284-293
Number of pages10
JournalGLIA
Volume56
Issue number3
DOIs
Publication statusPublished - Feb 2008

Fingerprint

Neuregulin-1
Oligodendroglia
Central Nervous System
Schwann Cells
Myelin Proteins
Neurons
Peripheral Nervous System
Brain
Spinal Ganglia
Neurites
Heterozygote
Optic Nerve
Myelin Sheath
Cell Differentiation
Spinal Cord
Protein Isoforms
Lipids

Keywords

  • Axon
  • CNS
  • Growth factor
  • Knock out
  • Myelin
  • Oligodendrocyte

ASJC Scopus subject areas

  • Immunology

Cite this

Taveggia, C., Thaker, P., Petrylak, A., Caporaso, G. L., Toews, A., Falls, D. L., ... Salzer, J. L. (2008). Type III neuregulin-1 promotes oligodendrocyte myelination. GLIA, 56(3), 284-293. https://doi.org/10.1002/glia.20612

Type III neuregulin-1 promotes oligodendrocyte myelination. / Taveggia, Carla; Thaker, Pratik; Petrylak, Ashley; Caporaso, Gregg L.; Toews, Arrel; Falls, Douglas L.; Einheber, Steven; Salzer, James L.

In: GLIA, Vol. 56, No. 3, 02.2008, p. 284-293.

Research output: Contribution to journalArticle

Taveggia, C, Thaker, P, Petrylak, A, Caporaso, GL, Toews, A, Falls, DL, Einheber, S & Salzer, JL 2008, 'Type III neuregulin-1 promotes oligodendrocyte myelination', GLIA, vol. 56, no. 3, pp. 284-293. https://doi.org/10.1002/glia.20612
Taveggia C, Thaker P, Petrylak A, Caporaso GL, Toews A, Falls DL et al. Type III neuregulin-1 promotes oligodendrocyte myelination. GLIA. 2008 Feb;56(3):284-293. https://doi.org/10.1002/glia.20612
Taveggia, Carla ; Thaker, Pratik ; Petrylak, Ashley ; Caporaso, Gregg L. ; Toews, Arrel ; Falls, Douglas L. ; Einheber, Steven ; Salzer, James L. / Type III neuregulin-1 promotes oligodendrocyte myelination. In: GLIA. 2008 ; Vol. 56, No. 3. pp. 284-293.
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