Types of endocrine cells in the human colon and rectum

R. Buffa, C. Capella, P. Fontana, L. Usellini, E. Solcia

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

At least four types of endocrine-like cells have been detected histochemically in the mucosa of the human colon and rectum, i.e. argentaffin cells storing 5-hydroxytryptamine (5 HT) and non-argentaffin cells reacting with glucagon, somatostatin and bovine pancreatic peptide (BPP) antibodies. Ultrastructurally, four main types and three rare types of endocrine-like cells have been identified. Among the former cells were: (1) argentaffin EC1 cells, known to store 5 HT and substance P, (2) poorly argyrophil L cells, corresponding to the glucagon-immunoreactive cells storing enteroglucagon or glucagon-like immunoreactivity (GL1), (3) inconstantly argyrophil F-like cells, possibly corresponding to BPP-immunoreactive cells, and (4) fairly argyrophil H cells of unknown function. Rare D cells, corresponding to somatostatin cells, N cells, corresponding to neurotensin cells, and P cells, of unknown function, have been also found.

Original languageEnglish
Pages (from-to)227-240
Number of pages14
JournalCell & Tissue Research
Volume192
Issue number2
DOIs
Publication statusPublished - Sep 1978

Fingerprint

Endocrine Cells
Somatostatin
Glucagon
Rectum
Serotonin
Colon
Cells
Glucagon-Like Peptides
Neurotensin
Peptides
Substance P
Antibodies
Enterochromaffin Cells
Somatostatin-Secreting Cells
Mucous Membrane
glucagon-like-immunoreactivity

Keywords

  • Endocrine cells
  • Human colon and rectum
  • Types
  • Ultrastructure, Histochemistry

ASJC Scopus subject areas

  • Anatomy
  • Clinical Biochemistry
  • Cell Biology

Cite this

Types of endocrine cells in the human colon and rectum. / Buffa, R.; Capella, C.; Fontana, P.; Usellini, L.; Solcia, E.

In: Cell & Tissue Research, Vol. 192, No. 2, 09.1978, p. 227-240.

Research output: Contribution to journalArticle

Buffa, R, Capella, C, Fontana, P, Usellini, L & Solcia, E 1978, 'Types of endocrine cells in the human colon and rectum', Cell & Tissue Research, vol. 192, no. 2, pp. 227-240. https://doi.org/10.1007/BF00220741
Buffa, R. ; Capella, C. ; Fontana, P. ; Usellini, L. ; Solcia, E. / Types of endocrine cells in the human colon and rectum. In: Cell & Tissue Research. 1978 ; Vol. 192, No. 2. pp. 227-240.
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