Typhlitis during second-line chemotherapy with pemetrexed in non-small cell lung cancer (NSCLC): A case report

Marcello Tiseo, Francesco Gelsomino, Marco Bartolotti, Matteo Pesenti Barili, Andrea Ardizzoni

Research output: Contribution to journalArticle


Neutropenic enterocolitis, or typhlitis, is an unusual acute complication of chemotherapy-induced neutropenia, characterized by inflammatory process involving colon and/or small bowel that may progress to necrosis, haemorrhage, perforation and septicaemia. Typhlitis is usually seen in the setting of severe chemotherapy-induced neutropenia for acute leukaemia. Nevertheless, it is increasingly recognized as a complication of therapy in solid tumors. We present a case of typhlitis in a patient with advanced non-small cell lung cancer (NSCLC) who received pemetrexed, as second-line chemotherapy treatment.

Original languageEnglish
Pages (from-to)251-253
Number of pages3
JournalLung Cancer
Issue number2
Publication statusPublished - Aug 2009



  • Chemotherapy
  • Neutropenia
  • Non-small cell lung cancer
  • Pemetrexed
  • Second line
  • Typhlitis

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Cite this