Abstract
Catechol derivatives with lipophilic properties have been selectively synthesized by tyrosinase in high yield avoiding long and tedious protection/deprotection steps usually required in traditional procedures. The synthesis was effective also with immobilized tyrosinase able to perform for more runs. The novel catechols were evaluated against influenza A virus, that continue to represent a severe threat worldwide. A significant antiviral activity was observed in derivatives characterized by antioxidant activity and long carbon alkyl side-chains, suggesting the possibility of a new inhibition mechanism based on both redox and lipophilic properties.
Original language | English |
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Pages (from-to) | 7699-7708 |
Number of pages | 10 |
Journal | Bioorganic and Medicinal Chemistry |
Volume | 21 |
Issue number | 24 |
DOIs | |
Publication status | Published - Dec 15 2013 |
Keywords
- Antiviral
- Biocatalysis
- Catechols
- Immobilized tyrosinase
- Influenza A virus
ASJC Scopus subject areas
- Pharmaceutical Science
- Drug Discovery
- Organic Chemistry
- Molecular Medicine
- Molecular Biology
- Clinical Biochemistry
- Biochemistry