Abstract
We studied tyrosine hydroxylase (TH) gene variants in mood disorders using linkage disequilibrium techniques. One hundred and forty-five inpatients affected by bipolar (n = 88) and unipolar (n = 57) disorders, and 84 healthy controls, were typed for TH variants using polymerase chain reaction (PCR) amplification. TH was associated with mood disorder, with all affected subjects presenting an excess of TH(*)2 allele (χ2 = 8.30, d.f. = 1; P= 0.004) and lack of the TH(*)1 allele (χ2 = 6.90, d.f. = 1, P = 0.009). Linkage disequilibrium analyses confirmed the association. Our results suggest a moderate linkage disequilibrium of TH variants with mood disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 169-174 |
| Number of pages | 6 |
| Journal | Molecular Psychiatry |
| Volume | 3 |
| Issue number | 2 |
| Publication status | Published - 1998 |
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Keywords
- Association
- Bipolar disorder
- Linkage disequilibrium
- Mood disorder
- Tyrosine hydroxylase
- Unipolar disorder
ASJC Scopus subject areas
- Molecular Biology
- Psychiatry and Mental health
Cite this
Tyrosine hydroxylase gene in linkage disequilibrium with mood disorders. / Serretti, A.; Macciardi, F.; Cusin, C.; Verga, M.; Pedrini, S.; Smeraldi, E.
In: Molecular Psychiatry, Vol. 3, No. 2, 1998, p. 169-174.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tyrosine hydroxylase gene in linkage disequilibrium with mood disorders
AU - Serretti, A.
AU - Macciardi, F.
AU - Cusin, C.
AU - Verga, M.
AU - Pedrini, S.
AU - Smeraldi, E.
PY - 1998
Y1 - 1998
N2 - We studied tyrosine hydroxylase (TH) gene variants in mood disorders using linkage disequilibrium techniques. One hundred and forty-five inpatients affected by bipolar (n = 88) and unipolar (n = 57) disorders, and 84 healthy controls, were typed for TH variants using polymerase chain reaction (PCR) amplification. TH was associated with mood disorder, with all affected subjects presenting an excess of TH(*)2 allele (χ2 = 8.30, d.f. = 1; P= 0.004) and lack of the TH(*)1 allele (χ2 = 6.90, d.f. = 1, P = 0.009). Linkage disequilibrium analyses confirmed the association. Our results suggest a moderate linkage disequilibrium of TH variants with mood disorders.
AB - We studied tyrosine hydroxylase (TH) gene variants in mood disorders using linkage disequilibrium techniques. One hundred and forty-five inpatients affected by bipolar (n = 88) and unipolar (n = 57) disorders, and 84 healthy controls, were typed for TH variants using polymerase chain reaction (PCR) amplification. TH was associated with mood disorder, with all affected subjects presenting an excess of TH(*)2 allele (χ2 = 8.30, d.f. = 1; P= 0.004) and lack of the TH(*)1 allele (χ2 = 6.90, d.f. = 1, P = 0.009). Linkage disequilibrium analyses confirmed the association. Our results suggest a moderate linkage disequilibrium of TH variants with mood disorders.
KW - Association
KW - Bipolar disorder
KW - Linkage disequilibrium
KW - Mood disorder
KW - Tyrosine hydroxylase
KW - Unipolar disorder
UR - http://www.scopus.com/inward/record.url?scp=0031919877&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031919877&partnerID=8YFLogxK
M3 - Article
C2 - 9577842
AN - SCOPUS:0031919877
VL - 3
SP - 169
EP - 174
JO - Molecular Psychiatry
JF - Molecular Psychiatry
SN - 1359-4184
IS - 2
ER -