Tyrosine hydroxylase gene in linkage disequilibrium with mood disorders

A. Serretti; F. Macciardi; C. Cusin; M. Verga; S. Pedrini; E. Smeraldi

Tyrosine hydroxylase gene in linkage disequilibrium with mood disorders

A. Serretti, F. Macciardi, C. Cusin, M. Verga, S. Pedrini, E. Smeraldi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

We studied tyrosine hydroxylase (TH) gene variants in mood disorders using linkage disequilibrium techniques. One hundred and forty-five inpatients affected by bipolar (n = 88) and unipolar (n = 57) disorders, and 84 healthy controls, were typed for TH variants using polymerase chain reaction (PCR) amplification. TH was associated with mood disorder, with all affected subjects presenting an excess of TH(*)2 allele (χ² = 8.30, d.f. = 1; P= 0.004) and lack of the TH(*)1 allele (χ² = 6.90, d.f. = 1, P = 0.009). Linkage disequilibrium analyses confirmed the association. Our results suggest a moderate linkage disequilibrium of TH variants with mood disorders.

Original language	English
Pages (from-to)	169-174
Number of pages	6
Journal	Molecular Psychiatry
Volume	3
Issue number	2
Publication status	Published - 1998

Keywords

Association
Bipolar disorder
Linkage disequilibrium
Mood disorder
Tyrosine hydroxylase
Unipolar disorder

ASJC Scopus subject areas

Molecular Biology
Psychiatry and Mental health

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title = "Tyrosine hydroxylase gene in linkage disequilibrium with mood disorders",

abstract = "We studied tyrosine hydroxylase (TH) gene variants in mood disorders using linkage disequilibrium techniques. One hundred and forty-five inpatients affected by bipolar (n = 88) and unipolar (n = 57) disorders, and 84 healthy controls, were typed for TH variants using polymerase chain reaction (PCR) amplification. TH was associated with mood disorder, with all affected subjects presenting an excess of TH(*)2 allele (χ2 = 8.30, d.f. = 1; P= 0.004) and lack of the TH(*)1 allele (χ2 = 6.90, d.f. = 1, P = 0.009). Linkage disequilibrium analyses confirmed the association. Our results suggest a moderate linkage disequilibrium of TH variants with mood disorders.",

keywords = "Association, Bipolar disorder, Linkage disequilibrium, Mood disorder, Tyrosine hydroxylase, Unipolar disorder",

author = "A. Serretti and F. Macciardi and C. Cusin and M. Verga and S. Pedrini and E. Smeraldi",

year = "1998",

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T1 - Tyrosine hydroxylase gene in linkage disequilibrium with mood disorders

AU - Serretti, A.

AU - Macciardi, F.

AU - Cusin, C.

AU - Verga, M.

AU - Pedrini, S.

AU - Smeraldi, E.

PY - 1998

Y1 - 1998

N2 - We studied tyrosine hydroxylase (TH) gene variants in mood disorders using linkage disequilibrium techniques. One hundred and forty-five inpatients affected by bipolar (n = 88) and unipolar (n = 57) disorders, and 84 healthy controls, were typed for TH variants using polymerase chain reaction (PCR) amplification. TH was associated with mood disorder, with all affected subjects presenting an excess of TH(*)2 allele (χ2 = 8.30, d.f. = 1; P= 0.004) and lack of the TH(*)1 allele (χ2 = 6.90, d.f. = 1, P = 0.009). Linkage disequilibrium analyses confirmed the association. Our results suggest a moderate linkage disequilibrium of TH variants with mood disorders.

AB - We studied tyrosine hydroxylase (TH) gene variants in mood disorders using linkage disequilibrium techniques. One hundred and forty-five inpatients affected by bipolar (n = 88) and unipolar (n = 57) disorders, and 84 healthy controls, were typed for TH variants using polymerase chain reaction (PCR) amplification. TH was associated with mood disorder, with all affected subjects presenting an excess of TH(*)2 allele (χ2 = 8.30, d.f. = 1; P= 0.004) and lack of the TH(*)1 allele (χ2 = 6.90, d.f. = 1, P = 0.009). Linkage disequilibrium analyses confirmed the association. Our results suggest a moderate linkage disequilibrium of TH variants with mood disorders.

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KW - Bipolar disorder

KW - Linkage disequilibrium

KW - Mood disorder

KW - Tyrosine hydroxylase

KW - Unipolar disorder

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