Tyrosine hydroxylase gene in linkage disequilibrium with mood disorders

A. Serretti, F. Macciardi, C. Cusin, M. Verga, S. Pedrini, E. Smeraldi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We studied tyrosine hydroxylase (TH) gene variants in mood disorders using linkage disequilibrium techniques. One hundred and forty-five inpatients affected by bipolar (n = 88) and unipolar (n = 57) disorders, and 84 healthy controls, were typed for TH variants using polymerase chain reaction (PCR) amplification. TH was associated with mood disorder, with all affected subjects presenting an excess of TH(*)2 allele (χ2 = 8.30, d.f. = 1; P= 0.004) and lack of the TH(*)1 allele (χ2 = 6.90, d.f. = 1, P = 0.009). Linkage disequilibrium analyses confirmed the association. Our results suggest a moderate linkage disequilibrium of TH variants with mood disorders.

Original languageEnglish
Pages (from-to)169-174
Number of pages6
JournalMolecular Psychiatry
Volume3
Issue number2
Publication statusPublished - 1998

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Linkage Disequilibrium
Tyrosine 3-Monooxygenase
Mood Disorders
Genes
Alleles
Inpatients
Polymerase Chain Reaction

Keywords

  • Association
  • Bipolar disorder
  • Linkage disequilibrium
  • Mood disorder
  • Tyrosine hydroxylase
  • Unipolar disorder

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health

Cite this

Serretti, A., Macciardi, F., Cusin, C., Verga, M., Pedrini, S., & Smeraldi, E. (1998). Tyrosine hydroxylase gene in linkage disequilibrium with mood disorders. Molecular Psychiatry, 3(2), 169-174.

Tyrosine hydroxylase gene in linkage disequilibrium with mood disorders. / Serretti, A.; Macciardi, F.; Cusin, C.; Verga, M.; Pedrini, S.; Smeraldi, E.

In: Molecular Psychiatry, Vol. 3, No. 2, 1998, p. 169-174.

Research output: Contribution to journalArticle

Serretti, A, Macciardi, F, Cusin, C, Verga, M, Pedrini, S & Smeraldi, E 1998, 'Tyrosine hydroxylase gene in linkage disequilibrium with mood disorders', Molecular Psychiatry, vol. 3, no. 2, pp. 169-174.
Serretti A, Macciardi F, Cusin C, Verga M, Pedrini S, Smeraldi E. Tyrosine hydroxylase gene in linkage disequilibrium with mood disorders. Molecular Psychiatry. 1998;3(2):169-174.
Serretti, A. ; Macciardi, F. ; Cusin, C. ; Verga, M. ; Pedrini, S. ; Smeraldi, E. / Tyrosine hydroxylase gene in linkage disequilibrium with mood disorders. In: Molecular Psychiatry. 1998 ; Vol. 3, No. 2. pp. 169-174.
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