Tyrosine hydroxylase gene in linkage disequilibrium with mood disorders

A. Serretti, F. Macciardi, C. Cusin, M. Verga, S. Pedrini, E. Smeraldi

Research output: Contribution to journalArticlepeer-review


We studied tyrosine hydroxylase (TH) gene variants in mood disorders using linkage disequilibrium techniques. One hundred and forty-five inpatients affected by bipolar (n = 88) and unipolar (n = 57) disorders, and 84 healthy controls, were typed for TH variants using polymerase chain reaction (PCR) amplification. TH was associated with mood disorder, with all affected subjects presenting an excess of TH(*)2 allele (χ2 = 8.30, d.f. = 1; P= 0.004) and lack of the TH(*)1 allele (χ2 = 6.90, d.f. = 1, P = 0.009). Linkage disequilibrium analyses confirmed the association. Our results suggest a moderate linkage disequilibrium of TH variants with mood disorders.

Original languageEnglish
Pages (from-to)169-174
Number of pages6
JournalMolecular Psychiatry
Issue number2
Publication statusPublished - 1998


  • Association
  • Bipolar disorder
  • Linkage disequilibrium
  • Mood disorder
  • Tyrosine hydroxylase
  • Unipolar disorder

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health


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