Abstract
We studied tyrosine hydroxylase (TH) gene variants in mood disorders using linkage disequilibrium techniques. One hundred and forty-five inpatients affected by bipolar (n = 88) and unipolar (n = 57) disorders, and 84 healthy controls, were typed for TH variants using polymerase chain reaction (PCR) amplification. TH was associated with mood disorder, with all affected subjects presenting an excess of TH(*)2 allele (χ2 = 8.30, d.f. = 1; P= 0.004) and lack of the TH(*)1 allele (χ2 = 6.90, d.f. = 1, P = 0.009). Linkage disequilibrium analyses confirmed the association. Our results suggest a moderate linkage disequilibrium of TH variants with mood disorders.
Original language | English |
---|---|
Pages (from-to) | 169-174 |
Number of pages | 6 |
Journal | Molecular Psychiatry |
Volume | 3 |
Issue number | 2 |
Publication status | Published - 1998 |
Keywords
- Association
- Bipolar disorder
- Linkage disequilibrium
- Mood disorder
- Tyrosine hydroxylase
- Unipolar disorder
ASJC Scopus subject areas
- Molecular Biology
- Psychiatry and Mental health