Tyrosine kinase inhibitors for non-small-cell lung cancer: Finding patients who will be responsive

Mariacarmela Santarpia, Giuseppe Altavilla, Maria F. Salazar, Ignacio Magri, Giuseppe Pettineo, Sara Benecchi, Rafael Rosell

Research output: Contribution to journalArticle

Abstract

In recent years, the management of lung cancer has been moving towards molecular-guided treatment, and the best example of this new approach is the use of the tyrosine kinase inhibitors (TKIs) erlotinib and gefitinib in patients with mutations in the epidermal growth factor receptor (EGFR). Erlotinib was introduced as a second- and third-line therapy for advanced non-small-cell lung cancer and demonstrated a survival advantage over placebo in unselected patients. Gefitinb did not confer the same advantage but specific subgroups of patients obtained higher response rates. The discovery of EGFR mutations explained the molecular mechanism of sensitivity to TKIs, and several clinical trials have evaluated the efficacy of TKIs in EGFR-mutated patients. New molecular alterations involving different genes have also been described and associated with sensitivity or resistance to TKIs. The identification of molecular predictors of response can allow the selection of patients who will be the most likely to respond to erlotinib and gefitinib.

Original languageEnglish
Pages (from-to)413-424
Number of pages12
JournalExpert Review of Respiratory Medicine
Volume5
Issue number3
DOIs
Publication statusPublished - Jun 2011

Keywords

  • acquired resistance
  • EGFR mutations
  • microRNAs
  • non-small-cell lung cancer
  • NSCLC
  • TKIs
  • tyrosine kinase inhibitors

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Immunology and Allergy
  • Public Health, Environmental and Occupational Health

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  • Cite this

    Santarpia, M., Altavilla, G., Salazar, M. F., Magri, I., Pettineo, G., Benecchi, S., & Rosell, R. (2011). Tyrosine kinase inhibitors for non-small-cell lung cancer: Finding patients who will be responsive. Expert Review of Respiratory Medicine, 5(3), 413-424. https://doi.org/10.1586/ers.11.27