Ubiquitinated neurites are associated with preamyloid and cerebral amyloid β deposits in patients with hereditary cerebral hemorrhage with amyloidosis Dutch type

Fabrizio Tagliavini, Giorgio Giaccone, Orso Bugiani, Blas Frangione

Research output: Contribution to journalArticle

Abstract

Here ditary cerebral hemorrhage with amyloidosis Dutch type (HCHWA-D) is characterized clinically by recurrent strokes and pathologically by deposition of amyloid β (Aβ) in cerebral vessel walls and, to a lesser extent, in the neuropil. Distinct from Alzheimer's disease, amyloid formation in HCHWA-D is not associated with neurofibrillary changes. Since a central issue in the pathophysiology of Alzheimer's disease and related conditions is the role of Aβ in the neurodegencrative process, we investigated HCHWA-D brains for the presence of neuritic abnormalities using antibodies to ubiquitin and to phosphorylated neurofilaments. The study showed that amyloid deposits in the vessel walls and in the neuropil were surrounded by abnormal ubiquitinated neurites, suggesting that Aβ deposition induces neuritic changes.

Original languageEnglish
Pages (from-to)267-271
Number of pages5
JournalActa Neuropathologica
Volume85
Issue number3
DOIs
Publication statusPublished - Feb 1993

Fingerprint

Amyloid Plaques
Cerebral Hemorrhage
Amyloidosis
Neurites
Neuropil
Amyloid
Alzheimer Disease
Intermediate Filaments
Ubiquitin
Stroke
Antibodies
Brain
Cerebral hemorrhage with amyloidosis, hereditary, Dutch type

Keywords

  • Alzheimer's disease
  • Amyloid β
  • Hereditary cerebral hemorrhage with amyloidosis Dutch type
  • Immunohistochemistry
  • Neurofilaments
  • Ubiquitin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

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abstract = "Here ditary cerebral hemorrhage with amyloidosis Dutch type (HCHWA-D) is characterized clinically by recurrent strokes and pathologically by deposition of amyloid β (Aβ) in cerebral vessel walls and, to a lesser extent, in the neuropil. Distinct from Alzheimer's disease, amyloid formation in HCHWA-D is not associated with neurofibrillary changes. Since a central issue in the pathophysiology of Alzheimer's disease and related conditions is the role of Aβ in the neurodegencrative process, we investigated HCHWA-D brains for the presence of neuritic abnormalities using antibodies to ubiquitin and to phosphorylated neurofilaments. The study showed that amyloid deposits in the vessel walls and in the neuropil were surrounded by abnormal ubiquitinated neurites, suggesting that Aβ deposition induces neuritic changes.",
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AU - Giaccone, Giorgio

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AU - Frangione, Blas

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N2 - Here ditary cerebral hemorrhage with amyloidosis Dutch type (HCHWA-D) is characterized clinically by recurrent strokes and pathologically by deposition of amyloid β (Aβ) in cerebral vessel walls and, to a lesser extent, in the neuropil. Distinct from Alzheimer's disease, amyloid formation in HCHWA-D is not associated with neurofibrillary changes. Since a central issue in the pathophysiology of Alzheimer's disease and related conditions is the role of Aβ in the neurodegencrative process, we investigated HCHWA-D brains for the presence of neuritic abnormalities using antibodies to ubiquitin and to phosphorylated neurofilaments. The study showed that amyloid deposits in the vessel walls and in the neuropil were surrounded by abnormal ubiquitinated neurites, suggesting that Aβ deposition induces neuritic changes.

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