TY - JOUR
T1 - Ugandan HIV-1 V3 loop sequences closely related to the U.S./European consensus
AU - Albert, Jan
AU - Franzén, Lena
AU - Jansson, Marianne
AU - Scarlatti, Gabriella
AU - Kataaha, Peter K.
AU - Katabira, E.
AU - Mubiro, F.
AU - Rydåker, Maria
AU - Rossi, Paolo
AU - Pettersson, Ulf
AU - Wigzell, Hans
PY - 1992
Y1 - 1992
N2 - The third variable (V3) loop of the human immunodeficiency virus type 1 (HIV-1) envelope protein is an important determinant for virus neutralization and cell tropism. V3 loop sequences from uncultured lymphocytes obtained in 1990 from 22 Ugandan HIV-1-infected patients could, with the exception of two patients' sequences, be divided into two groups (A and B) on the basis the V3 loop size and sequence. The V3 loop consensus sequences from both groups showed a high degree of homology to a U.S./European consensus, a characteristic also reflected by the results of peptide serology. In the case of group B the difference in sequence was only five amino acids. In contrast, the V3-flanking regions for both groups showed greater homology to an earlier (1986/1987) Ugandan consensus. The discovery of these two new Ugandan V3 loop genotypes, which are closely related to the U.S./European consensus, has implications for the understanding of the evolution of HIV-1 and for the future design of a vaccine for use in Africa.
AB - The third variable (V3) loop of the human immunodeficiency virus type 1 (HIV-1) envelope protein is an important determinant for virus neutralization and cell tropism. V3 loop sequences from uncultured lymphocytes obtained in 1990 from 22 Ugandan HIV-1-infected patients could, with the exception of two patients' sequences, be divided into two groups (A and B) on the basis the V3 loop size and sequence. The V3 loop consensus sequences from both groups showed a high degree of homology to a U.S./European consensus, a characteristic also reflected by the results of peptide serology. In the case of group B the difference in sequence was only five amino acids. In contrast, the V3-flanking regions for both groups showed greater homology to an earlier (1986/1987) Ugandan consensus. The discovery of these two new Ugandan V3 loop genotypes, which are closely related to the U.S./European consensus, has implications for the understanding of the evolution of HIV-1 and for the future design of a vaccine for use in Africa.
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U2 - 10.1016/0042-6822(92)90905-5
DO - 10.1016/0042-6822(92)90905-5
M3 - Article
C2 - 1519357
AN - SCOPUS:0026775244
VL - 190
SP - 674
EP - 681
JO - Virology
JF - Virology
SN - 0042-6822
IS - 2
ER -