Ultrasensitive assessment of residual HIV viraemia in HAART-treated patients with persistently undetectable plasma HIV-RNA: A cross-sectional evaluation

Stefano Bonora, Emanuele Nicastri, Andrea Calcagno, Daniel Gonzalez De Requena, Gabriella D'Ettorre, Loredana Sarmati, Lucia Palmisano, Vincenzo Vullo, Giovanni Di Perri, Massimo Andreoni

Research output: Contribution to journalArticle

Abstract

Improvements in HIV-RNA assays have made accurate detection of as few as 2 copies/ml possible. This study objective was the evaluation of ultrasensitive HIV-RNA quantitation (beneath current threshold: 50 copies/ml) in patients receiving different antiretroviral regimens. A cross-sectional, ultrasensitive measurement of HIV-RNA levels (detection limit: 2.5 HIV-RNA copies/ml) was performed in 154 HIV-1-infected patients receiving ARV therapy, all classed as full responders according to the 50 copies/ml cut-off. Patients were undergoing treatment with two nucleoside/nucleotide reverse transcriptase inhibitors (N/NtRTIs) plus nevirapine (NVP, n = 48), efavirenz (EFV, n = 57) or lopinavir/ ritonavir (LPV/r, n = 49). Undetectable HIV-RNA (3 (median = 240, SD = 194.5) was significantly lower in the LPV/r arm (P

Original languageEnglish
Pages (from-to)400-405
Number of pages6
JournalJournal of Medical Virology
Volume81
Issue number3
DOIs
Publication statusPublished - Mar 2009

Keywords

  • Efavirenz
  • Lopinavir
  • Nevirapine
  • Ultrasensitive HIV-RNA assay

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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    Bonora, S., Nicastri, E., Calcagno, A., De Requena, D. G., D'Ettorre, G., Sarmati, L., Palmisano, L., Vullo, V., Di Perri, G., & Andreoni, M. (2009). Ultrasensitive assessment of residual HIV viraemia in HAART-treated patients with persistently undetectable plasma HIV-RNA: A cross-sectional evaluation. Journal of Medical Virology, 81(3), 400-405. https://doi.org/10.1002/jmv.21405