Ultrasonic vocalization in response to unavoidable aversive stimuli in rats: Effects of benzodiazepines

V. Cuomo, R. Cagiano, M. A. De Salvia, M. A. Maselli, G. Renna, G. Racagni

Research output: Contribution to journalArticle

Abstract

The effects of two benzodiazepine derivatives (diazepam, 0.5-1 mg/kg; alprazolam, 1.25 - 2.5 mg/kg) on ultrasonic calling elicited in adult rats by unavoidable aversive stimuli (footshocks) were investigated. The results show that either diazepam or alprazolam affected the duration of ultrasonic calls. In particular, a significant decrease in the length of ultrasounds was found in the group of animals treated with these benzodiazepines. The effects of diazepam were counteracted by the benzodiazepine-antagonist Ro 15-1788. On the other hand, neither a neuroleptic agent, such as haloperidol (0.5 - 1 mg/kg), nor an antidepressant, such as desipramine (5 - 10 mg/kg) influenced the parameters of ultrasonic emission in this experimental situation. The present results suggest that ultrasonic vocalization in response to unavoidable aversive stimuli could be considered as a potential new tool for studying drugs with antianxiety properties.

Original languageEnglish
Pages (from-to)485-491
Number of pages7
JournalLife Sciences
Volume43
Issue number6
DOIs
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Pharmacology

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    Cuomo, V., Cagiano, R., De Salvia, M. A., Maselli, M. A., Renna, G., & Racagni, G. (1988). Ultrasonic vocalization in response to unavoidable aversive stimuli in rats: Effects of benzodiazepines. Life Sciences, 43(6), 485-491. https://doi.org/10.1016/0024-3205(88)90149-X