Ultrasonically guided fine-needle aspiration biopsy: A highly diagnostic procedure for hepatic tumors

F. Fornari, G. Civardi, L. Cavanna, S. Rossi, E. Buscarini, M. Di Stasi, G. Sbolli, L. Buscarini

Research output: Contribution to journalArticle

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Abstract

In 481 patients, with sonographically suspected neoplastic involvement of the liver, we performed an ultrasonically guided fine-needle aspiration biopsy with 22-gauge Chiba needle. In the 441 controlled cases, we obtained 68.5% true positive, 26.5% true negative, and 5% false negative, with a sensitivity of 93.2%, specificity of 100%, and overall accuracy of 95%. The true positive include 42.1% hepatocellular carcinomas, 28.1% metastases from known extrahepatic malignancy, 24.5% metastases from unknown primary site, 5% hepatic involvement by non-Hodgkin lymphomas, and 0.3% undetermined malignancy. Also, in a larger series, ultrasonically guided fine-needle biopsy confirms its high specificity and overall accuracy. The cytologic assessment of the obtained material is almost always adequate. The use of immediate cytologic staining reduces the number of passes in each lesion with absence of insufficient sampling. Biopsy with fine cutting needles should be reserved only for cases not diagnosed by cytology.

Original languageEnglish
Pages (from-to)1009-1013
Number of pages5
JournalAmerican Journal of Gastroenterology
Volume85
Issue number8
Publication statusPublished - 1990

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Fine Needle Biopsy
Needles
Neoplasm Metastasis
Liver
Non-Hodgkin's Lymphoma
Cell Biology
Hepatocellular Carcinoma
Neoplasms
Staining and Labeling
Biopsy
Sensitivity and Specificity

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Fornari, F., Civardi, G., Cavanna, L., Rossi, S., Buscarini, E., Di Stasi, M., ... Buscarini, L. (1990). Ultrasonically guided fine-needle aspiration biopsy: A highly diagnostic procedure for hepatic tumors. American Journal of Gastroenterology, 85(8), 1009-1013.

Ultrasonically guided fine-needle aspiration biopsy : A highly diagnostic procedure for hepatic tumors. / Fornari, F.; Civardi, G.; Cavanna, L.; Rossi, S.; Buscarini, E.; Di Stasi, M.; Sbolli, G.; Buscarini, L.

In: American Journal of Gastroenterology, Vol. 85, No. 8, 1990, p. 1009-1013.

Research output: Contribution to journalArticle

Fornari, F, Civardi, G, Cavanna, L, Rossi, S, Buscarini, E, Di Stasi, M, Sbolli, G & Buscarini, L 1990, 'Ultrasonically guided fine-needle aspiration biopsy: A highly diagnostic procedure for hepatic tumors', American Journal of Gastroenterology, vol. 85, no. 8, pp. 1009-1013.
Fornari, F. ; Civardi, G. ; Cavanna, L. ; Rossi, S. ; Buscarini, E. ; Di Stasi, M. ; Sbolli, G. ; Buscarini, L. / Ultrasonically guided fine-needle aspiration biopsy : A highly diagnostic procedure for hepatic tumors. In: American Journal of Gastroenterology. 1990 ; Vol. 85, No. 8. pp. 1009-1013.
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AU - Civardi, G.

AU - Cavanna, L.

AU - Rossi, S.

AU - Buscarini, E.

AU - Di Stasi, M.

AU - Sbolli, G.

AU - Buscarini, L.

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AB - In 481 patients, with sonographically suspected neoplastic involvement of the liver, we performed an ultrasonically guided fine-needle aspiration biopsy with 22-gauge Chiba needle. In the 441 controlled cases, we obtained 68.5% true positive, 26.5% true negative, and 5% false negative, with a sensitivity of 93.2%, specificity of 100%, and overall accuracy of 95%. The true positive include 42.1% hepatocellular carcinomas, 28.1% metastases from known extrahepatic malignancy, 24.5% metastases from unknown primary site, 5% hepatic involvement by non-Hodgkin lymphomas, and 0.3% undetermined malignancy. Also, in a larger series, ultrasonically guided fine-needle biopsy confirms its high specificity and overall accuracy. The cytologic assessment of the obtained material is almost always adequate. The use of immediate cytologic staining reduces the number of passes in each lesion with absence of insufficient sampling. Biopsy with fine cutting needles should be reserved only for cases not diagnosed by cytology.

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