Ultrasonographic and clinical assessment of peripheral enthesitis in patients with psoriatic arthritis, psoriasis, and fibromyalgia syndrome

The ULISSE study

Pierluigi Macchioni, Carlo Salvarani, Niccolò Possemato, Marwin Gutierrez, Walter Grassi, Stefania Gasparini, Carlo Perricone, Fabio Massimo Perrotta, Rosa Daniela Grembiale, Caterina Bruno, Cesare Tripolino, Marcello Govoni, Giovanni Ciancio, Ilaria Farina, Roberta Ramonda, Paola Frallonardo, Francesca Desiati, Raffaele Scarpa, Luisa Costa, Alen Zabotti & 7 others Salvatore De Vita, Rita Maria D’Attino, Giuliana Gualberti, Rocco Merolla, Umberto Di Luzio Paparatti, Raffaella Aldigeri, Antonio Marchesoni

Research output: Contribution to journalArticle

Abstract

Objective. The purpose of the ULISSE study was to evaluate the prevalence of clinical and ultrasonographic (US) entheseal involvement in patients with psoriatic arthritis (PsA), psoriasis, and fibromyalgia syndrome (FMS). Methods. In this cross-sectional multicenter study, patients with PsA and psoriasis (not taking systemic therapy) and FMS underwent a clinical evaluation of the entheses, and a B-mode and power Doppler examination of 6 pairs of entheses. Results. The study analyzed 140 patients with PsA, 51 with psoriasis, and 51 with FMS. Clinical and US examinations were performed in 1960 and 1680 entheses in the PsA group, and 714 and 612 entheses both in the psoriasis group and in the FMS group. In both per-patient and per-enthesis evaluation, the frequency of entheseal tenderness was higher in patients with FMS (92% of the patients and 46% of the entheses, compared with 66%/23% in the PsA group and 59%/18% in the psoriasis group). With US examination, signs of entheseal involvement were more frequent in both the per-patient and per-enthesis evaluation in PsA and psoriasis (about 90% of patients in both the PsA and psoriasis groups and 75% of patients in the FMS group had at least 1 site affected, and 54%, 41%, and 27% of the pairs of entheses in, respectively, PsA, psoriasis, and FMS patients showed at least 1 enthesis involved). Conclusion. The ULISSE study indicated that enthesitis is a common feature in patients with PsA, those with psoriasis, and in those with FMS if only clinical examination is used. US entheseal assessment showed findings more consistent with the 3 disorders.

Original languageEnglish
Pages (from-to)904-911
Number of pages8
JournalJournal of Rheumatology
Volume46
Issue number8
DOIs
Publication statusPublished - Aug 1 2019

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Psoriatic Arthritis
Fibromyalgia
Psoriasis
Multicenter Studies
Cross-Sectional Studies

Keywords

  • Enthesitis
  • Fibromyalgia syndrome
  • Psoriasis
  • Psoriatic arthritis
  • Ultrasonography

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Ultrasonographic and clinical assessment of peripheral enthesitis in patients with psoriatic arthritis, psoriasis, and fibromyalgia syndrome : The ULISSE study. / Macchioni, Pierluigi; Salvarani, Carlo; Possemato, Niccolò; Gutierrez, Marwin; Grassi, Walter; Gasparini, Stefania; Perricone, Carlo; Perrotta, Fabio Massimo; Grembiale, Rosa Daniela; Bruno, Caterina; Tripolino, Cesare; Govoni, Marcello; Ciancio, Giovanni; Farina, Ilaria; Ramonda, Roberta; Frallonardo, Paola; Desiati, Francesca; Scarpa, Raffaele; Costa, Luisa; Zabotti, Alen; De Vita, Salvatore; D’Attino, Rita Maria; Gualberti, Giuliana; Merolla, Rocco; Di Luzio Paparatti, Umberto; Aldigeri, Raffaella; Marchesoni, Antonio.

In: Journal of Rheumatology, Vol. 46, No. 8, 01.08.2019, p. 904-911.

Research output: Contribution to journalArticle

Macchioni, P, Salvarani, C, Possemato, N, Gutierrez, M, Grassi, W, Gasparini, S, Perricone, C, Perrotta, FM, Grembiale, RD, Bruno, C, Tripolino, C, Govoni, M, Ciancio, G, Farina, I, Ramonda, R, Frallonardo, P, Desiati, F, Scarpa, R, Costa, L, Zabotti, A, De Vita, S, D’Attino, RM, Gualberti, G, Merolla, R, Di Luzio Paparatti, U, Aldigeri, R & Marchesoni, A 2019, 'Ultrasonographic and clinical assessment of peripheral enthesitis in patients with psoriatic arthritis, psoriasis, and fibromyalgia syndrome: The ULISSE study', Journal of Rheumatology, vol. 46, no. 8, pp. 904-911. https://doi.org/10.3899/jrheum.171411
Macchioni, Pierluigi ; Salvarani, Carlo ; Possemato, Niccolò ; Gutierrez, Marwin ; Grassi, Walter ; Gasparini, Stefania ; Perricone, Carlo ; Perrotta, Fabio Massimo ; Grembiale, Rosa Daniela ; Bruno, Caterina ; Tripolino, Cesare ; Govoni, Marcello ; Ciancio, Giovanni ; Farina, Ilaria ; Ramonda, Roberta ; Frallonardo, Paola ; Desiati, Francesca ; Scarpa, Raffaele ; Costa, Luisa ; Zabotti, Alen ; De Vita, Salvatore ; D’Attino, Rita Maria ; Gualberti, Giuliana ; Merolla, Rocco ; Di Luzio Paparatti, Umberto ; Aldigeri, Raffaella ; Marchesoni, Antonio. / Ultrasonographic and clinical assessment of peripheral enthesitis in patients with psoriatic arthritis, psoriasis, and fibromyalgia syndrome : The ULISSE study. In: Journal of Rheumatology. 2019 ; Vol. 46, No. 8. pp. 904-911.
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abstract = "Objective. The purpose of the ULISSE study was to evaluate the prevalence of clinical and ultrasonographic (US) entheseal involvement in patients with psoriatic arthritis (PsA), psoriasis, and fibromyalgia syndrome (FMS). Methods. In this cross-sectional multicenter study, patients with PsA and psoriasis (not taking systemic therapy) and FMS underwent a clinical evaluation of the entheses, and a B-mode and power Doppler examination of 6 pairs of entheses. Results. The study analyzed 140 patients with PsA, 51 with psoriasis, and 51 with FMS. Clinical and US examinations were performed in 1960 and 1680 entheses in the PsA group, and 714 and 612 entheses both in the psoriasis group and in the FMS group. In both per-patient and per-enthesis evaluation, the frequency of entheseal tenderness was higher in patients with FMS (92{\%} of the patients and 46{\%} of the entheses, compared with 66{\%}/23{\%} in the PsA group and 59{\%}/18{\%} in the psoriasis group). With US examination, signs of entheseal involvement were more frequent in both the per-patient and per-enthesis evaluation in PsA and psoriasis (about 90{\%} of patients in both the PsA and psoriasis groups and 75{\%} of patients in the FMS group had at least 1 site affected, and 54{\%}, 41{\%}, and 27{\%} of the pairs of entheses in, respectively, PsA, psoriasis, and FMS patients showed at least 1 enthesis involved). Conclusion. The ULISSE study indicated that enthesitis is a common feature in patients with PsA, those with psoriasis, and in those with FMS if only clinical examination is used. US entheseal assessment showed findings more consistent with the 3 disorders.",
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T1 - Ultrasonographic and clinical assessment of peripheral enthesitis in patients with psoriatic arthritis, psoriasis, and fibromyalgia syndrome

T2 - The ULISSE study

AU - Macchioni, Pierluigi

AU - Salvarani, Carlo

AU - Possemato, Niccolò

AU - Gutierrez, Marwin

AU - Grassi, Walter

AU - Gasparini, Stefania

AU - Perricone, Carlo

AU - Perrotta, Fabio Massimo

AU - Grembiale, Rosa Daniela

AU - Bruno, Caterina

AU - Tripolino, Cesare

AU - Govoni, Marcello

AU - Ciancio, Giovanni

AU - Farina, Ilaria

AU - Ramonda, Roberta

AU - Frallonardo, Paola

AU - Desiati, Francesca

AU - Scarpa, Raffaele

AU - Costa, Luisa

AU - Zabotti, Alen

AU - De Vita, Salvatore

AU - D’Attino, Rita Maria

AU - Gualberti, Giuliana

AU - Merolla, Rocco

AU - Di Luzio Paparatti, Umberto

AU - Aldigeri, Raffaella

AU - Marchesoni, Antonio

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N2 - Objective. The purpose of the ULISSE study was to evaluate the prevalence of clinical and ultrasonographic (US) entheseal involvement in patients with psoriatic arthritis (PsA), psoriasis, and fibromyalgia syndrome (FMS). Methods. In this cross-sectional multicenter study, patients with PsA and psoriasis (not taking systemic therapy) and FMS underwent a clinical evaluation of the entheses, and a B-mode and power Doppler examination of 6 pairs of entheses. Results. The study analyzed 140 patients with PsA, 51 with psoriasis, and 51 with FMS. Clinical and US examinations were performed in 1960 and 1680 entheses in the PsA group, and 714 and 612 entheses both in the psoriasis group and in the FMS group. In both per-patient and per-enthesis evaluation, the frequency of entheseal tenderness was higher in patients with FMS (92% of the patients and 46% of the entheses, compared with 66%/23% in the PsA group and 59%/18% in the psoriasis group). With US examination, signs of entheseal involvement were more frequent in both the per-patient and per-enthesis evaluation in PsA and psoriasis (about 90% of patients in both the PsA and psoriasis groups and 75% of patients in the FMS group had at least 1 site affected, and 54%, 41%, and 27% of the pairs of entheses in, respectively, PsA, psoriasis, and FMS patients showed at least 1 enthesis involved). Conclusion. The ULISSE study indicated that enthesitis is a common feature in patients with PsA, those with psoriasis, and in those with FMS if only clinical examination is used. US entheseal assessment showed findings more consistent with the 3 disorders.

AB - Objective. The purpose of the ULISSE study was to evaluate the prevalence of clinical and ultrasonographic (US) entheseal involvement in patients with psoriatic arthritis (PsA), psoriasis, and fibromyalgia syndrome (FMS). Methods. In this cross-sectional multicenter study, patients with PsA and psoriasis (not taking systemic therapy) and FMS underwent a clinical evaluation of the entheses, and a B-mode and power Doppler examination of 6 pairs of entheses. Results. The study analyzed 140 patients with PsA, 51 with psoriasis, and 51 with FMS. Clinical and US examinations were performed in 1960 and 1680 entheses in the PsA group, and 714 and 612 entheses both in the psoriasis group and in the FMS group. In both per-patient and per-enthesis evaluation, the frequency of entheseal tenderness was higher in patients with FMS (92% of the patients and 46% of the entheses, compared with 66%/23% in the PsA group and 59%/18% in the psoriasis group). With US examination, signs of entheseal involvement were more frequent in both the per-patient and per-enthesis evaluation in PsA and psoriasis (about 90% of patients in both the PsA and psoriasis groups and 75% of patients in the FMS group had at least 1 site affected, and 54%, 41%, and 27% of the pairs of entheses in, respectively, PsA, psoriasis, and FMS patients showed at least 1 enthesis involved). Conclusion. The ULISSE study indicated that enthesitis is a common feature in patients with PsA, those with psoriasis, and in those with FMS if only clinical examination is used. US entheseal assessment showed findings more consistent with the 3 disorders.

KW - Enthesitis

KW - Fibromyalgia syndrome

KW - Psoriasis

KW - Psoriatic arthritis

KW - Ultrasonography

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