Ultrasonographic evaluation of cerebral arterial and venous haemodynamics in multiple sclerosis

A case-control study

Pasquale Marchione, Manuela Morreale, Patrizia Giacomini, Chiara Izzo, Simona Pontecorvo, Marta Altieri, Silvia Bernardi, Marco Frontoni, Ada Francia

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: Although recent studies excluded an association between Chronic Cerebrospinal Venous Insufficiency and Multiple Sclerosis (MS), controversial results account for some cerebrovascular haemodynamic impairment suggesting a dysfunction of cerebral autoregulation mechanisms. The aim of this cross-sectional, case-control study is to evaluate cerebral arterial inflow and venous outflow by means of a non-invasive ultrasound procedure in Relapsing Remitting (RR), Primary Progressive (PP) Multiple Sclerosis and age and sex-matched controls subjects. Material and Methods: All subjects underwent a complete extra-intracranial arterial and venous ultrasound assessment with a color-coded duplex sonography scanner and a transcranial doppler equipment, in both supine and sitting position by means of a tilting chair. Basal arterial and venous morphology and flow velocities, postural changes in mean flow velocities (MFV) of middle cerebral arteries (MCA), differences between cerebral venous outflow (CVF) in clinostatism and in the seated position (ΔCVF) and non-invasive cerebral perfusion pressure (CPP) were evaluated. Results: 85 RR-MS, 83 PP-MS and 82 healthy controls were included. ΔCVF was negative in 45/85 (52.9%) RR-MS, 63/83 (75.9%) PP-MS (p = 0.01) and 11/82 (13.4%) controls (p

Original languageEnglish
Article numbere111486
JournalPLoS One
Volume9
Issue number10
DOIs
Publication statusPublished - Oct 31 2014

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Chronic Progressive Multiple Sclerosis
sclerosis
Hemodynamics
hemodynamics
case-control studies
Multiple Sclerosis
Case-Control Studies
Relapsing-Remitting Multiple Sclerosis
Posture
Cerebrovascular Circulation
Flow velocity
Venous Insufficiency
Ultrasonics
Supine Position
Middle Cerebral Artery
Ultrasonography
Homeostasis
Color
autoregulation
Equipment and Supplies

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Marchione, P., Morreale, M., Giacomini, P., Izzo, C., Pontecorvo, S., Altieri, M., ... Francia, A. (2014). Ultrasonographic evaluation of cerebral arterial and venous haemodynamics in multiple sclerosis: A case-control study. PLoS One, 9(10), [e111486]. https://doi.org/10.1371/journal.pone.0111486

Ultrasonographic evaluation of cerebral arterial and venous haemodynamics in multiple sclerosis : A case-control study. / Marchione, Pasquale; Morreale, Manuela; Giacomini, Patrizia; Izzo, Chiara; Pontecorvo, Simona; Altieri, Marta; Bernardi, Silvia; Frontoni, Marco; Francia, Ada.

In: PLoS One, Vol. 9, No. 10, e111486, 31.10.2014.

Research output: Contribution to journalArticle

Marchione, P, Morreale, M, Giacomini, P, Izzo, C, Pontecorvo, S, Altieri, M, Bernardi, S, Frontoni, M & Francia, A 2014, 'Ultrasonographic evaluation of cerebral arterial and venous haemodynamics in multiple sclerosis: A case-control study', PLoS One, vol. 9, no. 10, e111486. https://doi.org/10.1371/journal.pone.0111486
Marchione, Pasquale ; Morreale, Manuela ; Giacomini, Patrizia ; Izzo, Chiara ; Pontecorvo, Simona ; Altieri, Marta ; Bernardi, Silvia ; Frontoni, Marco ; Francia, Ada. / Ultrasonographic evaluation of cerebral arterial and venous haemodynamics in multiple sclerosis : A case-control study. In: PLoS One. 2014 ; Vol. 9, No. 10.
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