Ultrasonographic intraoperative monitoring and follow-up of Kaposi's sarcoma nodules under treatment with intralesional vincristine

Gianluca Nazzaro, Giovanni Genovese, Athanasia Tourlaki, Emanuela Passoni, Emilio Berti, Lucia Brambilla

Research output: Contribution to journalArticle

Abstract

Background: Intralesional vincristine is an effective treatment for Kaposi's sarcoma (KS) nodules on the skin, but there is little evidence of its action through imaging techniques. Ultrasonography can be an adjunctive tool in the diagnosis and management of KS skin lesions, but data in the literature are few. Materials and Methods: Five patients with classic KS nodules were treated with intralesional vincristine. Ultrasonographic and color Doppler assessment were performed during vincristine injection and monitoring was repeated 1 and 3 months after the procedure. Partial response was defined as a reduction of more than 50% lesion volume and reduction of the vascular signal; complete response as a resolution of lesion associated with the absence of vascular signal. Results: Six KS nodules were included in the study. On ultrasonography examination, KS nodules appeared as oval or round, hypoechoic, homogeneous structures, with intralesional vascularization, more prominent in the deepest pole of the nodule. At month 1, 4 nodules achieved a complete response, while two nodules showed a partial response and were retreated with intralesional vincristine. At month 3, all lesions achieved a complete response. Conclusion: Ultrasonography may be a valuable tool in assessing clinical response to intralesional vincristine therapy of cutaneous KS nodules.

Original languageEnglish
Pages (from-to)200-203
JournalSkin Research and Technology
Volume25
Issue number2
DOIs
Publication statusPublished - 2019

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Intraoperative Monitoring
Kaposi's Sarcoma
Vincristine
Ultrasonography
Skin
Blood Vessels
Therapeutics
Color
Injections

Keywords

  • color Doppler examination
  • intralesional vincristine
  • Kaposi's sarcoma
  • ultrasonography

ASJC Scopus subject areas

  • Dermatology

Cite this

Ultrasonographic intraoperative monitoring and follow-up of Kaposi's sarcoma nodules under treatment with intralesional vincristine. / Nazzaro, Gianluca; Genovese, Giovanni; Tourlaki, Athanasia; Passoni, Emanuela; Berti, Emilio; Brambilla, Lucia.

In: Skin Research and Technology, Vol. 25, No. 2, 2019, p. 200-203.

Research output: Contribution to journalArticle

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abstract = "Background: Intralesional vincristine is an effective treatment for Kaposi's sarcoma (KS) nodules on the skin, but there is little evidence of its action through imaging techniques. Ultrasonography can be an adjunctive tool in the diagnosis and management of KS skin lesions, but data in the literature are few. Materials and Methods: Five patients with classic KS nodules were treated with intralesional vincristine. Ultrasonographic and color Doppler assessment were performed during vincristine injection and monitoring was repeated 1 and 3 months after the procedure. Partial response was defined as a reduction of more than 50{\%} lesion volume and reduction of the vascular signal; complete response as a resolution of lesion associated with the absence of vascular signal. Results: Six KS nodules were included in the study. On ultrasonography examination, KS nodules appeared as oval or round, hypoechoic, homogeneous structures, with intralesional vascularization, more prominent in the deepest pole of the nodule. At month 1, 4 nodules achieved a complete response, while two nodules showed a partial response and were retreated with intralesional vincristine. At month 3, all lesions achieved a complete response. Conclusion: Ultrasonography may be a valuable tool in assessing clinical response to intralesional vincristine therapy of cutaneous KS nodules.",
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T1 - Ultrasonographic intraoperative monitoring and follow-up of Kaposi's sarcoma nodules under treatment with intralesional vincristine

AU - Nazzaro, Gianluca

AU - Genovese, Giovanni

AU - Tourlaki, Athanasia

AU - Passoni, Emanuela

AU - Berti, Emilio

AU - Brambilla, Lucia

PY - 2019

Y1 - 2019

N2 - Background: Intralesional vincristine is an effective treatment for Kaposi's sarcoma (KS) nodules on the skin, but there is little evidence of its action through imaging techniques. Ultrasonography can be an adjunctive tool in the diagnosis and management of KS skin lesions, but data in the literature are few. Materials and Methods: Five patients with classic KS nodules were treated with intralesional vincristine. Ultrasonographic and color Doppler assessment were performed during vincristine injection and monitoring was repeated 1 and 3 months after the procedure. Partial response was defined as a reduction of more than 50% lesion volume and reduction of the vascular signal; complete response as a resolution of lesion associated with the absence of vascular signal. Results: Six KS nodules were included in the study. On ultrasonography examination, KS nodules appeared as oval or round, hypoechoic, homogeneous structures, with intralesional vascularization, more prominent in the deepest pole of the nodule. At month 1, 4 nodules achieved a complete response, while two nodules showed a partial response and were retreated with intralesional vincristine. At month 3, all lesions achieved a complete response. Conclusion: Ultrasonography may be a valuable tool in assessing clinical response to intralesional vincristine therapy of cutaneous KS nodules.

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